Curvularides A-E: Antifungal Hybrid Peptide-Polyketides from the Endophytic Fungus Curvularia geniculata

被引：41

作者：

Chomcheon, Porntep ^{[3
]}

Wiyakrutta, Suthep ^{[4
]}

Aree, Thammarat ^{[5
]}

Sriubolmas, Nongluksna ^{[6
,7
]}

Ngamrojanavanich, Nattaya ^{[5
]}

Mahidol, Chulabhorn ^{[1
,2
,8
]}

Ruchirawat, Somsak ^{[1
,2
,8
]}

Kittakoop, Prasat ^{[1
,2
]}

机构：

[1] Chulabhorn Grad Inst, Chulabhorn Res Inst, Bangkok 10210, Thailand

[2] Ctr Environm Hlth Toxicol & Management Chem ETM, Bangkok 10210, Thailand

[3] Chandrakasem Rajabhat Univ, Program Biotechnol, Fac Sci, Bangkok 10900, Thailand

[4] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand

[5] Chulalongkorn Univ, Fac Sci, Dept Chem, Bangkok 10330, Thailand

[6] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Biochem & Microbiol, Bangkok 10330, Thailand

[7] Chulalongkorn Univ, Fac Pharmaceut Sci, Ctr Bioact Nat Prod Marine Organisms & Endophyt F, Bangkok 10330, Thailand

[8] Mahidol Univ, Inst Mol Biosci, Chulabhorn Res Ctr, Bangkok 10400, Thailand

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 36期

关键词：

antifungal agents; natural products; peptides; phytochemistry; polyketides;

D O I：

10.1002/chem.201000652

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Five new hybrid peptide polyketides, curvularides A-E (1-5), were isolated from the endophytic fungus Curvularia geniculata, which was obtained from the limbs of Catunaregam tomentosa. Structure elucidation for curvularides A E (1-5) was accomplished by analysis of spectroscopic data, as well as by single-crystal X-ray crystallography. Curvularide B (2) exhibited antifungal activity against Candida albicans, and it also showed synergistic activity with a fluconazole drug.

引用

页码：11178 / 11185

页数：8

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