Curvularides A-E: Antifungal Hybrid Peptide-Polyketides from the Endophytic Fungus Curvularia geniculata

被引：41

作者：

Chomcheon, Porntep ^{[3
]}

Wiyakrutta, Suthep ^{[4
]}

Aree, Thammarat ^{[5
]}

Sriubolmas, Nongluksna ^{[6
,7
]}

Ngamrojanavanich, Nattaya ^{[5
]}

Mahidol, Chulabhorn ^{[1
,2
,8
]}

Ruchirawat, Somsak ^{[1
,2
,8
]}

Kittakoop, Prasat ^{[1
,2
]}

机构：

[1] Chulabhorn Grad Inst, Chulabhorn Res Inst, Bangkok 10210, Thailand

[2] Ctr Environm Hlth Toxicol & Management Chem ETM, Bangkok 10210, Thailand

[3] Chandrakasem Rajabhat Univ, Program Biotechnol, Fac Sci, Bangkok 10900, Thailand

[4] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand

[5] Chulalongkorn Univ, Fac Sci, Dept Chem, Bangkok 10330, Thailand

[6] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Biochem & Microbiol, Bangkok 10330, Thailand

[7] Chulalongkorn Univ, Fac Pharmaceut Sci, Ctr Bioact Nat Prod Marine Organisms & Endophyt F, Bangkok 10330, Thailand

[8] Mahidol Univ, Inst Mol Biosci, Chulabhorn Res Ctr, Bangkok 10400, Thailand

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 36期

关键词：

antifungal agents; natural products; peptides; phytochemistry; polyketides;

D O I：

10.1002/chem.201000652

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Five new hybrid peptide polyketides, curvularides A-E (1-5), were isolated from the endophytic fungus Curvularia geniculata, which was obtained from the limbs of Catunaregam tomentosa. Structure elucidation for curvularides A E (1-5) was accomplished by analysis of spectroscopic data, as well as by single-crystal X-ray crystallography. Curvularide B (2) exhibited antifungal activity against Candida albicans, and it also showed synergistic activity with a fluconazole drug.

引用

页码：11178 / 11185

页数：8

共 29 条

[1] Antifungal susceptibility of South African oral yeast isolates from HIV/AIDS patients and healthy individuals [J].

Blignaut, E ;

Messer, S ;

Hollis, RJ ;

Pfaller, MA .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2002, 44 (02) :169-174

[2] NUCLEAR MAGNETIC-RESONANCE ENANTIOMER REAGENTS - CONFIGURATIONAL CORRELATIONS VIA NUCLEAR MAGNETIC-RESONANCE CHEMICAL-SHIFTS OF DIASTEREOMERIC MANDELATE, O-METHYLMANDELATE, AND ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETATE (MTPA) ESTERS [J].

DALE, JA ;

MOSHER, HS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (02) :512-519

[3]

Doyle A., 1997, Mammalian cell culture

[4] MUSCLE: multiple sequence alignment with high accuracy and high throughput [J].

Edgar, RC .

NUCLEIC ACIDS RESEARCH, 2004, 32 (05) :1792-1797

[5]

Eliopoulos G.M., 1991, Antibiotics in Laboratory Medicine, V3rd, P432

[6] (+)-7-iso-Jasmonoyl-L-isoleucine is the endogenous bioactive jasmonate [J].

Fonseca, Sandra ;

Chini, Andrea ;

Hamberg, Mats ;

Adie, Bruce ;

Porzel, Andrea ;

Kramell, Robert ;

Miersch, Otto ;

Wasternack, Claus ;

Solano, Roberto .

NATURE CHEMICAL BIOLOGY, 2009, 5 (05) :344-350

[7] Bioactive chemical constituents of two endophytic fungi [J].

Hussain, Hidayat ;

Krohn, Karsten ;

Ullah, Zia ;

Draeger, Siegfried ;

Schulz, Barbara .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2007, 35 (12) :898-900

[8] STRUCTURE OF CORONATINE [J].

ICHIHARA, A ;

SHIRAISHI, K ;

SATO, H ;

SAKAMURA, S ;

NISHIYAMA, K ;

SAKAI, R ;

FURUSAKI, A ;

MATSUMOTO, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (02) :636-637

[9] Xanthones and Oxepino[2,3-b]chromones from Three Endophytic Fungi [J].

Krohn, Karsten ;

Kouam, Simeon F. ;

Kuigoua, Guy M. ;

Hussain, Hidayat ;

Cludius-Brandt, Stephan ;

Floerke, Ulrich ;

Kurtan, Tibor ;

Pescitelli, Gennaro ;

Di Bari, Lorenzo ;

Draeger, Siegfried ;

Schulz, Barbara .

CHEMISTRY-A EUROPEAN JOURNAL, 2009, 15 (44) :12121-12132

[10]

National Committee for Clinical Laboratory Standards, 2002, M27A2 NAT COMM CLIN

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