Microwave-assisted synthesis of novel 2,3-disubstituted imidazo[1,2-a] pyridines via one-pot three component reactions

被引：37

作者：

Karamthulla, Shaik ^{[1
]}

Khan, Md. Nasim ^{[1
]}

Choudhury, Lokman H. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Patna 800013, Bihar, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 25期

关键词：

3-COMPONENT DOMINO REACTIONS; MULTICOMPONENT REACTIONS; ORGANIC-SYNTHESIS; ANNULATED PYRIDINES; MOLECULAR-IODINE; C-NUCLEOSIDES; DERIVATIVES; CYCLIZATION; PYRROLES; ACCESS;

D O I：

10.1039/c4ra16298f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An expeditious one-pot, metal-free, three-component reaction of arylglyoxals, cyclic 1,3-dicarbonyls and 2-aminopyridines in the presence of molecular iodine under microwave irradiation is reported. A wide variety of 2,3-disubstituted imidazo[1,2-a] pyridine derivatives can be synthesized in good to very good yields using this methodology. The salient features of this methodology are: metal-free, short reaction time, good yields, use of microwave heating and no harmful by-products.

引用

页码：19724 / 19733

页数：10

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