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Effect of Liraglutide on Arterial Inflammation Assessed as [18F]FDG Uptake in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial
被引:32
作者:

Ripa, Rasmus S.
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Rigshosp, Dept Clin Physiol Nucl Med & PET & Cluster Mol Im, Dept Biomed Sci, Copenhagen, Denmark
Univ Copenhagen, Copenhagen, Denmark Rigshosp, Dept Clin Physiol Nucl Med & PET & Cluster Mol Im, Dept Biomed Sci, Copenhagen, Denmark

Zobel, Emilie H.
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Steno Diabet Ctr Copenhagen, Niels Steensens Vej 2, Gentofte, Denmark Rigshosp, Dept Clin Physiol Nucl Med & PET & Cluster Mol Im, Dept Biomed Sci, Copenhagen, Denmark

von Scholten, Bernt J.
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Steno Diabet Ctr Copenhagen, Niels Steensens Vej 2, Gentofte, Denmark
Novo Nordisk AS, Soborg, Denmark Rigshosp, Dept Clin Physiol Nucl Med & PET & Cluster Mol Im, Dept Biomed Sci, Copenhagen, Denmark

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Diaz, Lars J.
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Steno Diabet Ctr Copenhagen, Niels Steensens Vej 2, Gentofte, Denmark Rigshosp, Dept Clin Physiol Nucl Med & PET & Cluster Mol Im, Dept Biomed Sci, Copenhagen, Denmark

Curovic, Viktor R.
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Steno Diabet Ctr Copenhagen, Niels Steensens Vej 2, Gentofte, Denmark Rigshosp, Dept Clin Physiol Nucl Med & PET & Cluster Mol Im, Dept Biomed Sci, Copenhagen, Denmark

Hansen, Tine W.
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Steno Diabet Ctr Copenhagen, Niels Steensens Vej 2, Gentofte, Denmark Rigshosp, Dept Clin Physiol Nucl Med & PET & Cluster Mol Im, Dept Biomed Sci, Copenhagen, Denmark

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Kjaer, Andreas
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Rigshosp, Dept Clin Physiol Nucl Med & PET & Cluster Mol Im, Dept Biomed Sci, Copenhagen, Denmark
Univ Copenhagen, Copenhagen, Denmark Rigshosp, Dept Clin Physiol Nucl Med & PET & Cluster Mol Im, Dept Biomed Sci, Copenhagen, Denmark
机构:
[1] Rigshosp, Dept Clin Physiol Nucl Med & PET & Cluster Mol Im, Dept Biomed Sci, Copenhagen, Denmark
[2] Univ Copenhagen, Copenhagen, Denmark
[3] Steno Diabet Ctr Copenhagen, Niels Steensens Vej 2, Gentofte, Denmark
[4] Novo Nordisk AS, Soborg, Denmark
关键词:
atherosclerosis;
cardiovascular diseases;
carotid arteries;
glucagon-like peptide 1;
inflammation;
Type;
2;
Diabetes;
EUROPEAN ASSOCIATION;
RECEPTOR AGONIST;
VASCULAR-DISEASE;
CAROTID-ARTERY;
F-18-FDG PET;
PLAQUE;
RISK;
APOE(-/-);
D O I:
10.1161/CIRCIMAGING.120.012174
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Background: The mechanism behind the cardiovascular protection observed with human GLP-1 RA (glucagon-like peptide-1 receptor agonists) in type 2 diabetes is unknown. We hypothesized that treatment with the GLP-1 RA liraglutide had a positive effect on vascular inflammation. Methods: LIRAFLAME (Effect of liraglutide on vascular inflammation in type-2 diabetes: A randomized, placebocontrolled, double-blind, parallel clinical PET/CT trial) was a double-blind, randomized controlled trial performed at a single university hospital clinic in Denmark. Patients with type 2 diabetes were via computer-generated randomization list assigned (1:1) liraglutide up to 1.8 mg or placebo once daily for 26 weeks. The primary end point was change in vascular inflammation over 26 weeks assessed by [F-18]-fluorodeoxyglucose positron emission tomography/computed tomography. Analyses were based on intention-to-treat. Key secondary outcomes included change in other indices of atherosclerosis. Results: Between October 26, 2017, and August 16, 2019, 147 patients were screened and 102 were randomly assigned to liraglutide (n=51) or placebo (n=51) and 99 (97%) completed the trial. Change in the [F-18]-fluorodeoxyglucose positron emission tomography measure of vascular inflammation (active-segment target-to-background ratio) did not differ between treatment groups: change from baseline to 26 weeks was -0.04 (95% CI, -0.17 to 0.08) in the liraglutide group compared with -0.09 (-0.19 to 0.01) in the placebo group (mean difference, 0.05 [95% CI, -0.11 to 0.21], P=0.53). Secondary analyses restricted to [F-18]-fluorodeoxyglucose positron emission tomography of the carotid arteries as well as other indices of atherosclerosis confirmed the primary result. We performed an explorative analysis of interaction between treatment group and history of cardiovascular disease (P=0.052). Conclusions: In this low to moderate risk population with type 2 diabetes, liraglutide did not change vascular inflammation assessed as [F-18]-fluorodeoxyglucose uptake compared with placebo. An explorative analysis indicated a possible effect in persons with history of cardiovascular disease, in line with current guidelines where liraglutide is recommended to patients with history of cardiovascular disease. Registration: URL: ; Unique identifier: NCT03449654.
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- [1] QUANTIFICATION OF CORONARY-ARTERY CALCIUM USING ULTRAFAST COMPUTED-TOMOGRAPHY[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1990, 15 (04) : 827 - 832AGATSTON, AS论文数: 0 引用数: 0 h-index: 0机构: UNIV MIAMI,SCH MED,MIAMI,FL 33152JANOWITZ, WR论文数: 0 引用数: 0 h-index: 0机构: UNIV MIAMI,SCH MED,MIAMI,FL 33152HILDNER, FJ论文数: 0 引用数: 0 h-index: 0机构: UNIV MIAMI,SCH MED,MIAMI,FL 33152ZUSMER, NR论文数: 0 引用数: 0 h-index: 0机构: UNIV MIAMI,SCH MED,MIAMI,FL 33152VIAMONTE, M论文数: 0 引用数: 0 h-index: 0机构: UNIV MIAMI,SCH MED,MIAMI,FL 33152DETRANO, R论文数: 0 引用数: 0 h-index: 0机构: UNIV MIAMI,SCH MED,MIAMI,FL 33152
- [2] 18Fluorodeoxyglucose Accumulation in Arterial Tissues Determined by PET Signal Analysis[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 74 (09) : 1220 - 1232Al-Mashhadi, Rozh H.论文数: 0 引用数: 0 h-index: 0机构: Aarhus Univ, Dept Clin Med, Aarhus, Denmark Aarhus Univ Hosp, Dept Radiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus, Denmark Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark Aarhus Univ, Dept Clin Med, Aarhus, DenmarkTolbod, Lars P.论文数: 0 引用数: 0 h-index: 0机构: Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark Aarhus Univ, Dept Clin Med, Aarhus, DenmarkBloch, Lars O.论文数: 0 引用数: 0 h-index: 0机构: Aarhus Univ, Dept Clin Med, Aarhus, Denmark MR Ctr, Aarhus, Denmark Aarhus Univ, Dept Clin Med, Aarhus, DenmarkBjorklund, Martin M.论文数: 0 引用数: 0 h-index: 0机构: Aarhus Univ, Dept Clin Med, Aarhus, Denmark Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark Ctr Invest Cardiovasc Carlos III, Madrid, Spain Aarhus Univ, Dept Clin Med, Aarhus, DenmarkNasr, Zahra P.论文数: 0 引用数: 0 h-index: 0机构: Aarhus Univ, Dept Clin Med, Aarhus, Denmark Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark Aarhus Univ, Dept Clin Med, Aarhus, DenmarkAl-Mashhadi, Zheer论文数: 0 引用数: 0 h-index: 0机构: Aarhus Univ, Dept Clin Med, Aarhus, Denmark Aarhus Univ, Dept Clin Med, Aarhus, DenmarkWinterdahl, Michael论文数: 0 引用数: 0 h-index: 0机构: Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark Aarhus Univ, Dept Clin Med, Aarhus, DenmarkFrokiaer, Jorgen论文数: 0 引用数: 0 h-index: 0机构: Aarhus Univ, Dept Clin Med, Aarhus, Denmark Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark Aarhus Univ, Dept Clin Med, Aarhus, DenmarkFalk, Erling论文数: 0 引用数: 0 h-index: 0机构: Aarhus Univ, Dept Clin Med, Aarhus, Denmark Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark Aarhus Univ, Dept Clin Med, Aarhus, DenmarkBentzon, Jacob F.论文数: 0 引用数: 0 h-index: 0机构: Aarhus Univ, Dept Clin Med, Aarhus, Denmark Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark Ctr Invest Cardiovasc Carlos III, Madrid, Spain Aarhus Univ, Dept Clin Med, Aarhus, Denmark
- [3] Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4[J]. DIABETES, 2010, 59 (04) : 1030 - 1037Arakawa, Masayuki论文数: 0 引用数: 0 h-index: 0机构: Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, Japan Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, Japan论文数: 引用数: h-index:机构:Azuma, Kosuke论文数: 0 引用数: 0 h-index: 0机构: Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, Japan Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, JapanEbato, Chie论文数: 0 引用数: 0 h-index: 0机构: Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, Japan Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, JapanGoto, Hiromasa论文数: 0 引用数: 0 h-index: 0机构: Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, Japan Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, JapanNomiyama, Takashi论文数: 0 引用数: 0 h-index: 0机构: Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, Japan Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, JapanFujitani, Yoshio论文数: 0 引用数: 0 h-index: 0机构: Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, Japan Juntendo Univ, Grad Sch Med, Ctr Therapeut Innovat Diabet, Tokyo, Japan Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, JapanHirose, Takahisa论文数: 0 引用数: 0 h-index: 0机构: Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, Japan Juntendo Univ, Grad Sch Med, Ctr Therapeut Innovat Diabet, Tokyo, Japan Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, JapanKawamori, Ryuzo论文数: 0 引用数: 0 h-index: 0机构: Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, Japan Juntendo Univ, Grad Sch Med, Ctr Therapeut Innovat Diabet, Tokyo, Japan Juntendo Univ, Grad Sch Med, Sportol Ctr, Tokyo, Japan Juntendo Univ, Grad Sch Med, Ctr Beta Cell Biol & Regenerat, Tokyo, Japan Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, JapanWatada, Hirotaka论文数: 0 引用数: 0 h-index: 0机构: Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, Japan Juntendo Univ, Grad Sch Med, Sportol Ctr, Tokyo, Japan Juntendo Univ, Grad Sch Med, Dept Med Metab & Endocrinol, Tokyo, Japan
- [4] Sirtuin 6 Expression and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Incretin Treatment[J]. DIABETES, 2015, 64 (04) : 1395 - 1406Balestrieri, Maria Luisa论文数: 0 引用数: 0 h-index: 0机构: Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalyRizzo, Maria Rosaria论文数: 0 引用数: 0 h-index: 0机构: Univ Naples 2, Dept Med Surg Neurol Aging & Metab Sci, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalyBarbieri, Michelangela论文数: 0 引用数: 0 h-index: 0机构: Univ Naples 2, Dept Med Surg Neurol Aging & Metab Sci, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalyPaolisso, Pasquale论文数: 0 引用数: 0 h-index: 0机构: Univ Naples 2, Dept Med Surg Neurol Aging & Metab Sci, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalyD'Onofrio, Nunzia论文数: 0 引用数: 0 h-index: 0机构: Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalyGiovane, Alfonso论文数: 0 引用数: 0 h-index: 0机构: Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalySiniscalchi, Mario论文数: 0 引用数: 0 h-index: 0机构: Cardarelli Hosp, Dept Cardiol, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalyMinicucci, Fabio论文数: 0 引用数: 0 h-index: 0机构: Cardarelli Hosp, Dept Cardiol, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalySardu, Celestino论文数: 0 引用数: 0 h-index: 0机构: Univ Naples 2, Dept Med Surg Neurol Aging & Metab Sci, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalyD'Andrea, Davide论文数: 0 引用数: 0 h-index: 0机构: Cardarelli Hosp, Dept Cardiol, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalyMauro, Ciro论文数: 0 引用数: 0 h-index: 0机构: Cardarelli Hosp, Dept Cardiol, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalyFerraraccio, Franca论文数: 0 引用数: 0 h-index: 0机构: Univ Naples 2, Dept Clin Publ & Prevent Med, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalyServillo, Luigi论文数: 0 引用数: 0 h-index: 0机构: Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalyChirico, Fabio论文数: 0 引用数: 0 h-index: 0机构: Cardarelli Hosp, Dept Neurosurg, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalyCaiazzo, Pasquale论文数: 0 引用数: 0 h-index: 0机构: Cardarelli Hosp, Dept Neurosurg, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalyPaolisso, Giuseppe论文数: 0 引用数: 0 h-index: 0机构: Univ Naples 2, Dept Med Surg Neurol Aging & Metab Sci, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, ItalyMarfella, Raffaele论文数: 0 引用数: 0 h-index: 0机构: Univ Naples 2, Dept Med Surg Neurol Aging & Metab Sci, Naples, Italy Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, Italy
- [5] Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM) on PET imaging of atherosclerosis[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2016, 43 (04) : 780 - 792Bucerius, Jan论文数: 0 引用数: 0 h-index: 0机构: Maastricht Univ, Med Ctr, Dept Nucl Med, NL-6200 MD Maastricht, Netherlands Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht CARIM, NL-6200 MD Maastricht, Netherlands Rhein Westfal TH Aachen, Univ Hosp, Dept Nucl Med, D-52062 Aachen, Germany Maastricht Univ, Med Ctr MUMC, Dept Nucl Med, P Debyelaan 25, NL-6229 HX Maastricht, Netherlands Maastricht Univ, Med Ctr MUMC, Cardiovasc Res Inst CARIM, P Debyelaan 25, NL-6229 HX Maastricht, Netherlands Maastricht Univ, Med Ctr, Dept Nucl Med, NL-6200 MD Maastricht, NetherlandsHyafil, Fabien论文数: 0 引用数: 0 h-index: 0机构: Hop Xavier Bichat, AP HP, DHU FIRE, Dept Nucl Med,Inserm 1148, Paris, France Tech Univ Munich, Klinikum Rechts Isar, Dept Nucl Med, D-80290 Munich, Germany Maastricht Univ, Med Ctr, Dept Nucl Med, NL-6200 MD Maastricht, NetherlandsVerberne, Hein J.论文数: 0 引用数: 0 h-index: 0机构: Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, NL-1105 AZ Amsterdam, Netherlands Maastricht Univ, Med Ctr, Dept Nucl Med, NL-6200 MD Maastricht, NetherlandsSlart, Riemer H. J. A.论文数: 0 引用数: 0 h-index: 0机构: Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, Groningen, Netherlands Univ Twente, Fac Sci & Technol, Dept Biomed Photon Imaging, POB 217, NL-7500 AE Enschede, Netherlands Maastricht Univ, Med Ctr, Dept Nucl Med, NL-6200 MD Maastricht, NetherlandsLindner, Oliver论文数: 0 引用数: 0 h-index: 0机构: Heart & Diabet Ctr NRW, Inst Radiol, Nucl Med & Mol Imaging, Bad Oeynhausen, Germany Maastricht Univ, Med Ctr, Dept Nucl Med, NL-6200 MD Maastricht, NetherlandsSciagra, Roberto论文数: 0 引用数: 0 h-index: 0机构: Univ Florence, Dept Expt & Clin Biomed Sci, Nucl Med Unit, Florence, Italy Maastricht Univ, Med Ctr, Dept Nucl Med, NL-6200 MD Maastricht, NetherlandsAgostini, Denis论文数: 0 引用数: 0 h-index: 0机构: Normandie Univ, CHU Cote Nacre, Dept Nucl Med, Caen, France Maastricht Univ, Med Ctr, Dept Nucl Med, NL-6200 MD Maastricht, NetherlandsUebleis, Christopher论文数: 0 引用数: 0 h-index: 0机构: Univ Munich, Dept Clin Radiol, Munich, Germany Maastricht Univ, Med Ctr, Dept Nucl Med, NL-6200 MD Maastricht, NetherlandsGimelli, Alessia论文数: 0 引用数: 0 h-index: 0机构: Fdn Toscana Gabriele Monasterio, Pisa, Italy Maastricht Univ, Med Ctr, Dept Nucl Med, NL-6200 MD Maastricht, NetherlandsHacker, Marcus论文数: 0 引用数: 0 h-index: 0机构: Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, Div Nucl Med, Vienna, Austria Maastricht Univ, Med Ctr, Dept Nucl Med, NL-6200 MD Maastricht, Netherlands
- [6] 2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)[J]. DIABETES CARE, 2020, 43 (02) : 487 - 493Buse, John B.论文数: 0 引用数: 0 h-index: 0机构: Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27515 USA Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27515 USAWexler, Deborah J.论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA Harvard Med Sch, Boston, MA 02115 USA Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27515 USATsapas, Apostolos论文数: 0 引用数: 0 h-index: 0机构: Aristotle Univ Thessaloniki, Med Dept 2, Thessaloniki, Greece Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27515 USA论文数: 引用数: h-index:机构:Mingrone, Geltrude论文数: 0 引用数: 0 h-index: 0机构: Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy Univ Cattolica Sacro Cuore, Rome, Italy Kings Coll London, Diabet & Nutr Sci, London, England Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27515 USAMathieu, Chantal论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, UZ Gasthuisberg, Clin & Expt Endocrinol, Leuven, Belgium Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27515 USAD'Alessio, David A.论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Sch Med, Dept Med, Durham, NC 27706 USA Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27515 USADavies, Melanie J.论文数: 0 引用数: 0 h-index: 0机构: Univ Leicester, Leicester Gen Hosp, Diabet Res Ctr, Leicester, Leics, England Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27515 USA
- [7] Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events):: a randomised controlled trial[J]. LANCET, 2005, 366 (9493) : 1279 - 1289Dormandy, JA论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandCharbonnel, B论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandEckland, DJA论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandErdmann, E论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandMassi-Benedetti, M论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandKmoules, IK论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandSkene, AM论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandTan, MH论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandLefébvre, PJ论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandMurray, GD论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandStandl, E论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandWilcox, RG论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandWlhelmsen, L论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandBetteridge, J论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandBirkeland, K论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandGolay, A论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandHeine, RJ论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandKorányi, L论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandLaakso, M论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandMokán, M论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandNorkus, A论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandPirags, V论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandPodar, T论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandScheen, A论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandScherbaum, W论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandSchernthaner, G论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandSchmitz, O论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandSkrha, J论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandSmith, U论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, EnglandTaton, J论文数: 0 引用数: 0 h-index: 0机构: Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, England
- [8] Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018, 71 (21) : 2392 - 2401Everett, Brendan M.论文数: 0 引用数: 0 h-index: 0机构: Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Boston, MA USA Harvard Med Sch, Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA USA Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Boston, MA USADonath, Marc Y.论文数: 0 引用数: 0 h-index: 0机构: Univ Hosp Basel, Endocrinol Diabet & Metab, Basel, Switzerland Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Boston, MA USAPradhan, Aruna D.论文数: 0 引用数: 0 h-index: 0机构: Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Boston, MA USA VA Boston Med Ctr, Dept Med, Div Cardiovasc Med, West Roxbury, MA USA Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Boston, MA USAThuren, Tom论文数: 0 引用数: 0 h-index: 0机构: Novartis Pharmaceut, E Hanover, NJ USA Novartis Pharmaceut, Basel, Switzerland Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Boston, MA USAPais, Prem论文数: 0 引用数: 0 h-index: 0机构: St Johns Res Inst, Bangalore, Karnataka, India Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Boston, MA USANicolau, Jose C.论文数: 0 引用数: 0 h-index: 0机构: Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Inst Coracao InCor, Sao Paulo, Brazil Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Boston, MA USAGlynn, Robert J.论文数: 0 引用数: 0 h-index: 0机构: Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Boston, MA USA Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Boston, MA USALibby, Peter论文数: 0 引用数: 0 h-index: 0机构: Harvard Med Sch, Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA USA Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Boston, MA USARidker, Paul M.论文数: 0 引用数: 0 h-index: 0机构: Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Boston, MA USA Harvard Med Sch, Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA USA Harvard Med Sch, Ctr Cardiovasc Dis Prevent, Boston, MA USA
- [9] Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial[J]. LANCET, 2011, 378 (9802) : 1547 - 1559Fayad, Zahi A.论文数: 0 引用数: 0 h-index: 0机构: Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USA Mt Sinai Sch Med, Cardiovasc Inst, New York, NY 10029 USA Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USAMani, Venkatesh论文数: 0 引用数: 0 h-index: 0机构: Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USA Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USAWoodward, Mark论文数: 0 引用数: 0 h-index: 0机构: Univ Sydney, George Inst, Sydney, NSW 2006, Australia Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USAKallend, David论文数: 0 引用数: 0 h-index: 0机构: F Hoffmann La Roche Ltd, Basel, Switzerland Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USAAbt, Markus论文数: 0 引用数: 0 h-index: 0机构: Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USABurgess, Tracy论文数: 0 引用数: 0 h-index: 0机构: Hoffmann La Roche Inc, Nutley, NJ 07110 USA Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USAFuster, Valentin论文数: 0 引用数: 0 h-index: 0机构: Mt Sinai Sch Med, Cardiovasc Inst, New York, NY 10029 USA CNIC, Madrid, Spain Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USABallantyne, Christie M.论文数: 0 引用数: 0 h-index: 0机构: Baylor Coll Med, Methodist DeBakey Heart & Vasc Ctr, Houston, TX 77030 USA Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USAStein, Evan A.论文数: 0 引用数: 0 h-index: 0机构: Metab & Atherosclerosis Res Ctr, Cincinnati, OH USA Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USATardif, Jean-Claude论文数: 0 引用数: 0 h-index: 0机构: Univ Montreal, Montreal Heart Inst, Montreal, PQ, Canada Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USARudd, James H. F.论文数: 0 引用数: 0 h-index: 0机构: Univ Cambridge, Div Cardiovasc Med, Cambridge, England Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USAFarkouh, Michael E.论文数: 0 引用数: 0 h-index: 0机构: Mt Sinai Sch Med, Cardiovasc Inst, New York, NY 10029 USA Peter Munk Cardiac Ctr, Toronto, ON, Canada Li Ka Shing Knowledge Inst, Toronto, ON, Canada Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USATawakol, Ahmed论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Sch Med, Boston, MA USA Massachusetts Gen Hosp, Boston, MA 02114 USA Mt Sinai Sch Med, Dept Radiol, Translat & Mol Imaging Inst, 1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USA
- [10] The GLP-1 receptor agonist liraglutide inhibits progression of vascular disease via effects on atherogenesis, plaque stability and endothelial function in an ApoE-/- mouse model[J]. DIABETES & VASCULAR DISEASE RESEARCH, 2013, 10 (04) : 353 - 360论文数: 引用数: h-index:机构:Welungoda, Iresha论文数: 0 引用数: 0 h-index: 0机构: Monash Univ, Dept Pharmacol, Melbourne, Vic 3128, Australia Monash Univ, Dept Pharmacol, Melbourne, Vic 3128, AustraliaWiddop, Robert E.论文数: 0 引用数: 0 h-index: 0机构: Monash Univ, Dept Pharmacol, Melbourne, Vic 3128, Australia Monash Univ, Dept Pharmacol, Melbourne, Vic 3128, AustraliaSimpson, Richard W.论文数: 0 引用数: 0 h-index: 0机构: Monash Univ, Dept Med, Eastern Hlth Clin Sch, Melbourne, Vic 3128, Australia Eastern Hlth, Dept Endocrinol, Melbourne, Vic, Australia Monash Univ, Dept Pharmacol, Melbourne, Vic 3128, AustraliaDear, Anthony E.论文数: 0 引用数: 0 h-index: 0机构: Monash Univ, Dept Med, Eastern Hlth Clin Sch, Melbourne, Vic 3128, Australia Monash Univ, Dept Med, Translat Res Div, Eastern Clin Res Unit,Australian Ctr Blood Dis, Melbourne, Vic 3128, Australia Monash Univ, Dept Pharmacol, Melbourne, Vic 3128, Australia