Myelin and oligodendrocyte lineage cell dysfunctions: New players in the etiology and treatment of depression and stress-related disorders

被引：55

作者：

Boda, Enrica ^{[1
,2
]}

机构：

[1] Univ Turin, Dept Neurosci Rita Levi Montalcini, Turin, Italy

[2] Univ Turin, NICO, Reg Gonzole 10, I-10043 Turin, Italy

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 2021年 / 53卷 / 01期

关键词：

antidepressant; early life experience; myelination; neuromodulation; WHITE-MATTER ABNORMALITIES; DORSOLATERAL PREFRONTAL CORTEX; LATE-LIFE DEPRESSION; TREATMENT-RESISTANT DEPRESSION; SEIZURES INDUCE PROLIFERATION; FIBROBLAST GROWTH FACTOR-2; NG2-EXPRESSING GLIAL-CELLS; MAJOR DEPRESSION; NEUROTROPHIC FACTOR; GENDER-DIFFERENCES;

D O I：

10.1111/ejn.14621

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Depressive disorders are complex, multifactorial disorders that have been traditionally attributed exclusively to neuronal abnormalities. However, recent studies have increased our understanding of the contribution of glial cells-and particularly of oligodendroglia-to the pathogenesis and treatment outcome of depression and stress-related disorders. This review scrutinizes recent studies focusing on the neurosupportive functions exerted by myelin and oligodendrocyte lineage cells and their disruption in depression and stress-related disorders. It also illustrates how myelin and oligodendroglia respond to antidepressants and non-pharmacological treatment alternatives and proposes oligodendroglia-directed approaches as novel therapeutic options for depressive disorders.

引用

收藏

页码：281 / 297

页数：17

相关论文

共 195 条

[1] Frontal white matter microstructure and treatment response of late-life depression: A preliminary study [J].

Alexopoulos, GS ;

Kiosses, DN ;

Choi, SJ ;

Murphy, CF ;

Lim, KO .

AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (11) :1929-1932

[2]

Alonso G, 2000, GLIA, V31, P219, DOI 10.1002/1098-1136(200009)31:3<219::AID-GLIA30>3.0.CO

[3]

2-R

[4] Repetitive transcranial magnetic stimulation for treatment resistant depression: Re-establishing connections [J].

Anderson, Rodney J. ;

Hoy, Kate E. ;

Daskalakis, Zafiris J. ;

Fitzgerald, Paul B. .

CLINICAL NEUROPHYSIOLOGY, 2016, 127 (11) :3394-3405

[5] Neurodevelopmental origins of depressive disorders [J].

Ansorge, Mark S. ;

Hen, Rene ;

Gingrich, Jay A. .

CURRENT OPINION IN PHARMACOLOGY, 2007, 7 (01) :8-17

[6] Depression in multiple sclerosis: Review and theoretical proposal [J].

Arnett, Peter A. ;

Barwick, Fiona H. ;

Beeney, Joe E. .

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2008, 14 (05) :691-724

[7] Myelinogenic Plasticity of Oligodendrocyte Precursor Cells following Spinal Cord Contusion Injury [J].

Assinck, Peggy ;

Duncan, Greg J. ;

Plemel, Jason R. ;

Lee, Michael J. ;

Stratton, Jo A. ;

Manesh, Sohrab B. ;

Liu, Jie ;

Ramer, Leanne M. ;

Kang, Shin H. ;

Bergles, Dwight E. ;

Biernaskie, Jeff ;

Tetzlaff, Wolfram .

JOURNAL OF NEUROSCIENCE, 2017, 37 (36) :8635-8654

[8] Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder [J].

Aston, C ;

Jiang, L ;

Sokolov, BP .

MOLECULAR PSYCHIATRY, 2005, 10 (03) :309-322

[9] Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression [J].

Bae, Jae Nam ;

MacFall, James R. ;

Krishnan, K. Ranga R. ;

Payne, Martha E. ;

Steffens, David C. ;

Taylor, Warren D. .

BIOLOGICAL PSYCHIATRY, 2006, 60 (12) :1356-1363

[10] Postnatal Down-Regulation of the GABAA Receptor γ2 Subunit in Neocortical NG2 Cells Accompanies Synaptic-to-Extrasynaptic Switch in the GABAergic Transmission Mode [J].

Balia, Maddalena ;

Velez-Fort, Mateo ;

Passlick, Stefan ;

Schaefer, Christoph ;

Audinat, Etienne ;

Steinhaeuser, Christian ;

Seifert, Gerald ;

Angulo, Maria Cecilia .

CEREBRAL CORTEX, 2015, 25 (04) :1114-1123

← 1 2 3 4 5 6 7 8 9 10 →