HPP1 gene promoter methylation in pancreatic cancer: correlation with carcinogenesis and clinical implication

被引：1

作者：

Peng, Lisi ^{[1
]}

Zhuang, Lu ^{[1
]}

Lin, Kun ^{[1
]}

Yao, Yao ^{[1
]}

Zhang, Yang ^{[1
]}

Zhu, Chunping ^{[1
]}

Wang, Kaixuan ^{[1
]}

Huang, Haojie ^{[1
]}

Li, Zhaoshen ^{[1
]}

机构：

[1] Second Mil Med Univ, Changhai Hosp, Dept Gastroenterol, 168 Changhai Rd, Shanghai 200433, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2018年 / 11卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Pancreatic cancer; HPP1; methylation; diagnosis; DNA METHYLATION; PROGRESSION; ACTIVATION; PHENOTYPE; SMOKING; HEAD;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aberrant methylation of the promoter region in a tumor suppressor gene is a significant early event in carcinogenesis of pancreatic cancer. Methylation status of a tumor suppressor gene may be useful as a diagnostic marker for early detection of pancreatic cancer. The current study evaluated methylation status of the hyperplastic polyposis 1 (HPP1) gene transcriptional regulation region (TRR) in pancreatic cancer and normal tissue samples by bisulfite-specific PCR (BSP) cloningbased sequencing analysis and quantitative methylationspecific PCR (qMSP). Correlation of methylation with the clinicopathological characteristics of the pancreatic cancer patients was also assessed. The results demonstrated that the HPP1 promoter was significantly hypermethylated in the pancreatic cancer tissues compared with normal tissues and a significant correlation between HPP1 methylation level and tumor-node-metastasis stage was observed. Thus, our study suggests that methylation of the HPP1 gene is a potential clinically diagnostic and prognostic biomarker for pancreatic cancer.

引用

页码：3605 / 3611

页数：7

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