Apolipoprotein E gene polymorphism and left ventricular function in Iranian patients with thalassemia major

被引：9
作者：
Bazrgar, Masood [1 ]
Karimi, Mehran [2 ]
Peiravian, Farah [3 ]
Fathzadeh, Mohsen [1 ]
机构：
[1] Iranian Acad Ctr Educ Culture & Res ACECR, Fars Prov Branch, Human Genet Res Grp, Shiraz, Iran
[2] SUMS, Hematol Res Ctr, Shiraz, Iran
[3] SUMS, Fatemeh Zahra Hosp, Cooleys Anemia Cardiac Clin, Shiraz, Iran
来源：
HAEMATOLOGICA | 2007年 / 92卷 / 02期
关键词：
thalassemia; left ventricular function; apolipoprotein E;
D O I：
10.3324/haematol.10708
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Left ventricular (LV) failure is the main cause of death in thalassemia. Iron overload in patients with thalassemia leads to the formation of oxygen free radicals. Of the various apolipoprotein E (apoE) alleles, apoE4 is the least efficient in conditions of oxidative stress in comparison with apoE2 and apoE3. Our results showed that apoE4 is a genetic risk factor for LV dysfunction in thalassemia.
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收藏
页码：256 / 257
页数：2
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