Cell surface-based differentiation of cell types and cancer states using a gold nanoparticle-GFP based sensing array

被引：92

作者：

Bajaj, Avinash ^{[1
]}

Rana, Subinoy ^{[1
]}

Miranda, Oscar R. ^{[1
]}

Yawe, Joseph C. ^{[1
]}

Jerry, D. Joseph ^{[2
]}

Bunz, Uwe H. F. ^{[3
]}

Rotello, Vincent M. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

[2] Univ Massachusetts, Dept Vet & Anim Sci, Amherst, MA 01003 USA

[3] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

来源：

CHEMICAL SCIENCE | 2010年 / 1卷 / 01期

关键词：

SENSOR ARRAY; COLORIMETRIC IDENTIFICATION; PROTEINS;

D O I：

10.1039/c0sc00165a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold nanoparticle-green fluorescent protein (NP-GFP) based arrays have been created for rapid identification of mammalian cells on the basis of cell surface properties. Highly reproducible characteristic patterns were obtained from different cell types enabling the identification of cell types and cancer states. Using these arrays we could differentiate between isogenic normal, cancer and metastatic cell types using only similar to 5000 cells.

引用

页码：134 / 138

页数：5

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