Nucleophilic substitution of protected 2-amino-4-butanoic acid. An easy route to exotic amino acids and conformationally constrained peptides.

被引：13

作者：

Ciapetti, P

Mann, A

Shoenfelder, A

Taddei, M

机构：

[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

[2] Fac Pharm, CNRS, ERS 655, F-67401 Illkirch Graffenstaden, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(98)00628-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a series of novel alpha-amino acids based on the nucleophilic substitution of protected 2-amino-4-bromobutanoic acid (1) is described. Basic, acidic or neutral amino acids can be obtained; chimerical amino acids carrying a coenzyme type structure in the side chain, multifunctional amino acids for the synthesis of cross-linked peptides or dendrimers and conformationally constrained peptides can also be obtained. (C) 1998 Elsevier Science Ltd. ALI rights reserved.

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页码：3843 / 3846

页数：4

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