Diagnosis of oral precancer with optical coherence tomography

被引：57

作者：

Lee, Cheng-Kuang ^{[1
]}

Chi, Ting-Ta ^{[1
]}

Wu, Chiung-Ting ^{[1
]}

Tsai, Meng-Tsan ^{[2
]}

Chiang, Chun-Pin ^{[3
,4
]}

Yang, Chih-Chung ^{[1
,5
]}

机构：

[1] Natl Taiwan Univ, Inst Photon & Optoelect, Taipei 10617, Taiwan

[2] Chang Gung Univ, Dept Elect Engn, Tao Yuan 33302, Taiwan

[3] Natl Taiwan Univ, Grad Inst Oral Biol, Taipei 10048, Taiwan

[4] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Taipei 10048, Taiwan

[5] Natl Taiwan Univ, Dept Elect Engn, Taipei 10617, Taiwan

来源：

BIOMEDICAL OPTICS EXPRESS | 2012年 / 3卷 / 07期

关键词：

MALIGNANCY;

D O I：

10.1364/BOE.3.001632

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A procedure for computer analyzing an optical coherence tomography (OCT) image of normal and precancerous oral mucosae is demonstrated to reasonably plot the boundary between epithelium (EP) and lamina propria (LP) layers, determine the EP thickness, and estimate the range of dysplastic cell distribution based on standard deviation (SD) mapping. In this study, 54 normal oral mucosa, 39 oral mild dysplasia, and 44 oral moderate dysplasia OCT images are processed for evaluating the diagnosis statistics. Based on SD mapping in an OCT image, it is found that the laterally average range percentages of 70% SD maximum level in the EP layer is a reasonably good threshold for differentiating moderate dysplasia from mild dysplasia oral lesion based on the OCT image analysis. The sensitivity and specificity in diagnosis statistics can reach 82 and 90%, respectively. (C) 2012 Optical Society of America

引用

页码：1632 / 1646

页数：15

共 21 条

[1] Doppler optical coherence tomography to monitor the effect of photodynamic therapy on tissue morphology and perfusion
Aalders, Maurice C. G.
Triesscheijn, Martijn
Ruevekamp, Marjan
de Bruin, Martijn
Baas, Paul
Faber, Dirk J.
Stewart, Fiona A.
[J]. JOURNAL OF BIOMEDICAL OPTICS, 2006, 11 (04)
[2] [Anonymous], WHO DIS INJ COUNTR E
[3] Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography
Cense, B
Chen, TC
Park, BH
Pierce, MC
de Boer, JF
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 (08) : 2606 - 2612
[4] Chi AC., 2009, Oral and Maxillofacial Pathology, P388
[5] Detection and diagnosis of oral neoplasia with an optical coherence microscope
Clark, AL
Gillenwater, A
Alizadeh-Naderi, R
El-Naggar, AK
Richards-Kortum, R
[J]. JOURNAL OF BIOMEDICAL OPTICS, 2004, 9 (06) : 1271 - 1280
[6] DeCoro M, 2010, EXPERT REV ANTICANC, V10, P321, DOI [10.1586/era.09.191, 10.1586/ERA.09.191]
[7] Cancer statistics, 2005
Jemal, A
Murray, T
Ward, E
Samuels, A
Tiwari, RC
Ghafoor, A
Feuer, EJ
Thun, MJ
[J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2005, 55 (01) : 10 - 30
[8] In vitro examination of suspicious oral lesions using optical coherence tomography
Jerjes, Waseem
Upile, Tahwinder
Conn, Brendan
Hamdoon, Zaid
Betz, Christian S.
McKenzie, Gordon
Radhi, Hani
Vourvachis, Michael
El Maaytah, Mohammed
Sandison, Ann
Jay, Amrita
Hopper, Colin
[J]. BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 2010, 48 (01) : 18 - 25
[9] Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles
Kim, Chang Soo
Wilder-Smith, Petra
Ahn, Yeh-Chan
Liaw, Lih-Huei L.
Chen, Zhongping
Kwon, Young Jik
[J]. JOURNAL OF BIOMEDICAL OPTICS, 2009, 14 (03)
[10] Diagnosis of oral submucous fibrosis with optical coherence tomography
Lee, Cheng-Kuang
Tsai, Meng-Tsan
Lee, Hsiang-Chieh
Chen, Hsin-Ming
Chiang, Chun-Pin
Wang, Yih-Ming
Yang, C. C.
[J]. JOURNAL OF BIOMEDICAL OPTICS, 2009, 14 (05)

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