Aurone: A biologically attractive scaffold as anticancer agent

被引：75

作者：

Alsayari, Abdulrahman ^{[1
]}

Bin Muhsinah, Abdullatif ^{[1
]}

Hassan, Mohd Zaheen ^{[1
]}

Ahsan, Mohammed Jawed ^{[1
]}

Alshehri, Jaber Abdullah ^{[1
]}

Begum, Naseem ^{[2
]}

机构：

[1] King Khalid Univ, Coll Pharm, Abha 62529, Saudi Arabia

[2] King Khalid Univ, Coll Appl Med Sci, Abha 62529, Saudi Arabia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2019年 / 166卷

关键词：

Aurone; Flavonoid; Anticancer; Multidrug resistance; CANCER-CELL-LINES; FLAVONOID DERIVATIVES; NATURAL-PRODUCTS; FUNCTIONALIZED AURONES; IN-VITRO; INHIBITORS; DESIGN; DISCOVERY; MODULATION; TYROSINASE;

D O I：

10.1016/j.ejmech.2019.01.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aurones are very simple, promising anticancer lead molecules containing three rings (A, B and C). A very slight structural variation in the aurones elicits diverse affinity and specificity towards different molecular targets. The present review discusses the design, discovery and development of natural and synthetic aurones as small molecule anticancer agents. Detailed structure-activity relationship and intermolecular interactions at different targets are also discussed. Due to their rare occurrence in nature and minimal mention in literature, the anticancer potential of aurones is rather recent but in constant progress. (C) 2019 Elsevier Masson SAS. All rights reserved.

引用

页码：417 / 431

页数：15

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