Hypercalcemia due to all trans retinoic acid in the treatment of acute promyelocytic leukemia potentiated by voriconazole

被引：21
作者：
Bennett, MT
Sirrs, S
Yeung, JK
Smith, CA
机构：
[1] Univ British Columbia, Dept Med, Vancouver, BC, Canada
[2] Univ British Columbia, Div Endocrinol, Vancouver, BC, Canada
[3] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada
[4] Univ British Columbia, Div Hematol, Vancouver, BC, Canada
来源：
LEUKEMIA & LYMPHOMA | 2005年 / 46卷 / 12期
关键词：
hypercalcemia; ATRA; all-trans-retinoic acid; APL; acute promyelocytic leukemia; voriconazole;
D O I：
10.1080/10428190500235298
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
All-trans-retinoic acid ( ATRA) is a new and effective treatment of acute promyelocytic leukemia. It has many side-effects, including the retinoic acid syndrome and Sweet's syndrome. There have been only nine cases of hypercalcemia associated with ATRA described in the literature. We discuss a case of hypercalcemia, which we believe was due to inhibition of cytochrome P450 function by voriconizole when used concomitantly with ATRA.
引用
收藏
页码：1829 / 1831
页数：3
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