E-selectin and P-selectin expression in endothelium of leprosy skin lesions

被引：9

作者：

de Souza, Juarez ^{[1
]}

de Sousa, Jorge Rodrigues ^{[2
]}

Hirai, Kelly Emi ^{[1
]}

Silva, Luciana Mota ^{[1
]}

Fuzii, Hellen Thais ^{[2
]}

Dias, Leonidas Braga, Jr. ^{[1
]}

Oliveira Carneiro, Francisca Regina ^{[1
]}

de Souza Aarao, Tinara Leila ^{[1
]}

Simoes Quaresma, Juarez Antonio ^{[1
,2
]}

机构：

[1] Univ Estado Para, Ctr Ciencias Biol & Saude, Belem, Para, Brazil

[2] UFPA, Nucleo Med Trop, BR-66055240 Belem, Para, Brazil

来源：

ACTA TROPICA | 2015年 / 149卷

关键词：

Leprosy; Immunopathology; Endothelium; GLYCOPROTEIN LIGAND-1 PSGL-1; T-LYMPHOCYTE MIGRATION; ADHESION MOLECULES; INFLAMMATION; RECRUITMENT;

D O I：

10.1016/j.actatropica.2015.06.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Leprosy is an infectious-contagious disease whose clinical evolution depends on the immune response pattern of the host. Adhesion molecules and leukocyte migration from blood to tissue are of the utmost importance for the recognition and elimination of infectious pathogens. Selectins are transmembrane glycoproteins that share a similar structural organization and can be divided into three types according to their site of expression. The biopsies were cut into 5 mu m thick sections and submitted to immunohistochemistry using antibodies against E-selectin and P-selectin. The number of E-selectin-positive cells was significantly higher in the tuberculoid form than in the lepromatous form. The immunostaining pattern of P-selectin differed from that of E-selectin. Analysis showed a larger number of endothelial cells expressing CD62P in the lepromatous form compared to the tuberculoid form. The presence of these adhesins in the endothelium contributing to or impairing the recruitment of immune cells to inflamed tissue and consequently influences the pattern of immune response and the clinical presentation of the disease. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：227 / 231

页数：5

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