Heightened intrathecal release of proinflammatory cytokines in Creutzfeldt-Jakob disease

被引：40

作者：

Sharief, MK ^{[1
]}

Green, A

Dick, JPR

Gawler, J

Thompson, EJ

机构：

[1] United Med & Dent Sch Guys & St Thomas Hosp, Guys Hosp, Dept Neurol, London SE1 9RT, England

[2] Neurol Inst, Dept Neuroimmunol, London, England

[3] Royal London Hosp, Dept Neurol, London E1 1BB, England

来源：

NEUROLOGY | 1999年 / 52卷 / 06期

关键词：

D O I：

10.1212/WNL.52.6.1289

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors report high intrathecal release of tumor necrosis factor alpha (TNF-alpha) and interleukin (TL)-1 beta in five patients with sporadic or new-variant Creutzfeldt-Jakob disease (CJD) without activation of the humoral or lymphocytic immune responses. Increased release of TNP-alpha and IL-1 beta was also detected in some patients with progressive dementias. CJD is associated with a local cerebral host response that involves the release of proinflammatory cytokines.

引用

页码：1289 / 1291

页数：3

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