Late onset Alzheimer's disease in older people

被引:88
作者
Isik, Ahmet Turan [1 ]
机构
[1] Gulhane Mil Med Acad, Div Geriatr Med, Dept Internal Med, Ankara, Turkey
关键词
Alzheimer disease; dementia; elderly; BRAIN; PATHOGENESIS; DIAGNOSIS; DEMENTIA; BETA; MECHANISMS; PREVENTION; SYMPTOMS; INSULIN; IMPACT;
D O I
10.2147/CIA.S11718
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Dementia has become a common diagnosis in aging populations, and the numbers will increase in the forthcoming years. Alzheimer's disease (AD) is the most common form of dementia in the elderly, accounting for 50%-56% of cases at autopsy and in clinical series. Nowadays, the number of people affected by AD is rapidly increasing, and more than 35 million people worldwide have AD, a condition characterized by deterioration of memory and other cognitive domains, and leading to death 3-9 years after diagnosis. The number of patients with AD, the most common cause of disability in the elderly, is set to rise dramatically. Therefore, it is important for clinicians to recognize early signs and symptoms of dementia and to note potentially modifiable risk factors and early disease markers.
引用
收藏
页码:307 / 311
页数:5
相关论文
共 41 条
[1]  
Alzheimer's Association, 2010, Alzheimers Dement, V6, P158, DOI 10.1016/j.jalz.2010.01.009
[2]  
[Anonymous], UND STAG SYMPT ALZH
[3]   Synaptic degeneration in Alzheimer's disease [J].
Arendt, Thomas .
ACTA NEUROPATHOLOGICA, 2009, 118 (01) :167-179
[4]   Commentary on "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." Dementia risk indices: A framework for identifying individuals with a high dementia risk [J].
Barnes, Deborah E. ;
Covinsky, Kenneth E. ;
Whitmer, Rachel A. ;
Kuller, Lewis H. ;
Lopez, Oscar L. ;
Yaffe, Kristine .
ALZHEIMERS & DEMENTIA, 2010, 6 (02) :138-141
[5]   Treatment strategies for the behavioral symptoms of Alzheimer's disease: Focus on early pharmacologic intervention [J].
Beier, Manju T. .
PHARMACOTHERAPY, 2007, 27 (03) :399-411
[6]   NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].
BRAAK, H ;
BRAAK, E .
ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259
[7]   Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease:: Stereologic analysis of prefrontal cortex area 9 [J].
Bussière, T ;
Giannakopoulos, P ;
Bouras, C ;
Perl, DP ;
Morrison, JH ;
Hof, PR .
JOURNAL OF COMPARATIVE NEUROLOGY, 2003, 463 (03) :281-302
[8]   Synaptic slaughter in Alzheimer's disease [J].
Coleman, PD ;
Yao, PJ .
NEUROBIOLOGY OF AGING, 2003, 24 (08) :1023-1027
[9]   Mechanisms of neuronal death in Alzheimer's disease [J].
Cotman, CW ;
Su, JH .
BRAIN PATHOLOGY, 1996, 6 (04) :493-506
[10]  
de la Monte SM, 2005, J ALZHEIMERS DIS, V7, P45