Apoptosis induced by picolinic acid-related compounds in HL-60 cells

被引：25
|
作者：
Ogata, S [1 ]
Inoue, K [1 ]
Iwata, K [1 ]
Okumura, K [1 ]
Taguchi, H [1 ]
机构：
[1] Mie Univ, Fac Bioresources, Dept Life Sci, Mol & Cellular Biol Lab, Tsu, Mie 5148507, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2001年 / 65卷 / 10期
关键词：
niacin; picolinic acid; NAD; apoptosis; HL-60;
D O I：
10.1271/bbb.65.2337
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have found that niacin-related compounds, particularly picolinic acid, induced apoptosis in human leukemia cells. In this paper, we investigated whether various picolinic acid-related compounds had apoptosis-inducing activities or not. Particularly, fusaric acid, picolinaldehyde, nicotinaldehyde, 2-aminopyridine, and 3-aminopyridine also induced apoptosis in HL-60 cells. These results suggest that pyridine substituted with various groups and the consequent change of resonance structure may have an important role in the induction of apoptosis.
引用
收藏
页码：2337 / 2339
页数：3
相关论文
共 50 条
  • [41] Apoptosis of human leukemic HL-60 cells induced to differentiate by treatment with RA or DMSO
    SUN HONG
    YONGCHAO WANG(Key Laborutory of Cell Proliferation and Regulation Biology
    CellResearch, 1995, (02) : 181 - 186
  • [42] Involvement of hydrogen peroxide and hydroxyl radical in chemically induced apoptosis of HL-60 cells
    Ikeda, K
    Kajiwara, K
    Tanabe, E
    Tokumaru, S
    Kishida, E
    Masuzawa, Y
    Kojo, S
    BIOCHEMICAL PHARMACOLOGY, 1999, 57 (12) : 1361 - 1365
  • [43] Altered expression of nuclear matrix proteins in etoposide induced apoptosis in HL-60 cells
    Jin, ML
    Zhang, P
    Ding, MX
    Yun, JP
    Chen, PF
    Chen, YH
    Chew, YQ
    CELL RESEARCH, 2001, 11 (02) : 125 - 134
  • [44] Erianin induces apoptosis in human leukemia HL-60 cells
    Li, YM
    Wang, HY
    Liu, GQ
    ACTA PHARMACOLOGICA SINICA, 2001, 22 (11): : 1018 - 1022
  • [45] Effect of intracellular acidity and ionomycin on apoptosis in HL-60 cells
    Park, HJ
    Makepeace, CM
    Lyons, JC
    Song, CW
    EUROPEAN JOURNAL OF CANCER, 1996, 32A (03) : 540 - 546
  • [46] Regulation of Histone Acetylation and Apoptosis by Trichostatin in HL-60 Cells
    李新刚
    陈维凯
    谷俊侠
    崔国惠
    陈燕
    华中科技大学学报(医学英德文版), 2004, (06) : 572 - 574
  • [47] Induction of apoptosis in HL-60 cells treated with medicinal herbs
    Nishida, S
    Kikuichi, S
    Yoshioka, S
    Tsubaki, M
    Fujii, Y
    Matsuda, H
    Kubo, M
    Irimajiri, K
    AMERICAN JOURNAL OF CHINESE MEDICINE, 2003, 31 (04): : 551 - 562
  • [48] Anaplasma phagocytophilum infection induces apoptosis in HL-60 cells
    Karki, Pratap
    Ijdo, Jacob W.
    WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2011, 27 (11) : 2741 - 2746
  • [49] Ribose enhances retinoic acid-induced differentiation of HL-60 cells
    Freeman, Melanie L.
    Mertens-Talcott, Susanne U.
    Cyr, John St.
    Percival, Susan S.
    NUTRITION RESEARCH, 2008, 28 (11) : 775 - 782
  • [50] Anaplasma phagocytophilum infection induces apoptosis in HL-60 cells
    Pratap Karki
    Jacob W. IJdo
    World Journal of Microbiology and Biotechnology, 2011, 27 : 2741 - 2746
12345