Apoptosis induced by picolinic acid-related compounds in HL-60 cells

被引：25
|
作者：
Ogata, S [1 ]
Inoue, K [1 ]
Iwata, K [1 ]
Okumura, K [1 ]
Taguchi, H [1 ]
机构：
[1] Mie Univ, Fac Bioresources, Dept Life Sci, Mol & Cellular Biol Lab, Tsu, Mie 5148507, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2001年 / 65卷 / 10期
关键词：
niacin; picolinic acid; NAD; apoptosis; HL-60;
D O I：
10.1271/bbb.65.2337
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have found that niacin-related compounds, particularly picolinic acid, induced apoptosis in human leukemia cells. In this paper, we investigated whether various picolinic acid-related compounds had apoptosis-inducing activities or not. Particularly, fusaric acid, picolinaldehyde, nicotinaldehyde, 2-aminopyridine, and 3-aminopyridine also induced apoptosis in HL-60 cells. These results suggest that pyridine substituted with various groups and the consequent change of resonance structure may have an important role in the induction of apoptosis.
引用
收藏
页码：2337 / 2339
页数：3
相关论文
共 50 条
  • [21] Ellagitannins from Terminalia calamansanai induced apoptosis in HL-60 cells
    Chen, Lih-Geeng
    Huang, Wen-Tsung
    Lee, Lain-Tze
    Wang, Ching-Chiung
    TOXICOLOGY IN VITRO, 2009, 23 (04) : 603 - 609
  • [22] IRON DEPRIVATION-INDUCED APOPTOSIS IN HL-60 CELLS
    FUKUCHI, K
    TOMOYASU, S
    TSURUOKA, N
    GOMI, K
    FEBS LETTERS, 1994, 350 (01) : 139 - 142
  • [23] Role of calcium in apoptosis of HL-60 cells induced by harringtonine
    Fang, M
    Zhang, HQ
    Xue, SB
    SCIENCE IN CHINA SERIES C-LIFE SCIENCES, 1998, 41 (06): : 600 - 607
  • [24] Chlorogenic acid induced apoptosis and inhibition of proliferation in human acute promyelocytic leukemia HL-60 cells
    Liu, Ya-Jing
    Zhou, Chang-Yang
    Qiu, Chun-Hong
    Lu, Xiu-Min
    Wang, Yong-Tang
    MOLECULAR MEDICINE REPORTS, 2013, 8 (04) : 1106 - 1110
  • [25] Role of calcium in apoptosis of HL-60 cells induced by harringtonine
    方敏
    张鸿卿
    薛绍白
    Science in China(Series C:Life Sciences), 1998, (06) : 600 - 607
  • [26] Apoptosis to HL-60 by humulone
    Tobe, H
    Kubota, M
    Yamaguchi, M
    Kocha, T
    Aoyagi, T
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1997, 61 (06) : 1027 - 1029
  • [27] Characterization of room temperature induced apoptosis in HL-60
    Shimura, M
    Ishizaka, Y
    Yuo, A
    Hatake, K
    Oshima, M
    Sasaki, T
    Takaku, F
    FEBS LETTERS, 1997, 417 (03) : 379 - 384
  • [28] Humic acid induces apoptosis in human premyelocytic leukemia HL-60 cells
    Yang, HL
    Hseu, YC
    Hseu, YT
    Lu, FJ
    Lin, E
    Lai, JS
    LIFE SCIENCES, 2004, 75 (15) : 1817 - 1831
  • [29] Identification of genes responsive to apoptosis in HL-60 cells
    Wei JIN2
    3Departmentof Vascular Surgery & Institute of Vascular Surgery of PLA
    4 Le p?le franco-chinois du science du vivant et génomique
    Acta Pharmacologica Sinica, 2004, (03) : 65 - 72
  • [30] Analogs of farnesylcysteine induce apoptosis in HL-60 cells
    Pérez-Sala, D
    Gilbert, BA
    Rando, RR
    Cañada, FJ
    FEBS LETTERS, 1998, 426 (03) : 319 - 324
12345