Apoptosis induced by picolinic acid-related compounds in HL-60 cells

被引：25
|
作者：
Ogata, S [1 ]
Inoue, K [1 ]
Iwata, K [1 ]
Okumura, K [1 ]
Taguchi, H [1 ]
机构：
[1] Mie Univ, Fac Bioresources, Dept Life Sci, Mol & Cellular Biol Lab, Tsu, Mie 5148507, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2001年 / 65卷 / 10期
关键词：
niacin; picolinic acid; NAD; apoptosis; HL-60;
D O I：
10.1271/bbb.65.2337
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have found that niacin-related compounds, particularly picolinic acid, induced apoptosis in human leukemia cells. In this paper, we investigated whether various picolinic acid-related compounds had apoptosis-inducing activities or not. Particularly, fusaric acid, picolinaldehyde, nicotinaldehyde, 2-aminopyridine, and 3-aminopyridine also induced apoptosis in HL-60 cells. These results suggest that pyridine substituted with various groups and the consequent change of resonance structure may have an important role in the induction of apoptosis.
引用
收藏
页码：2337 / 2339
页数：3
相关论文
共 50 条
  • [1] Apoptosis induced by nicotinamide-related compounds and quinolinic acid in HL-60 cells
    Ogata, S
    Takeuchi, M
    Fujita, H
    Shibata, K
    Okumura, K
    Taguchi, H
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2000, 64 (02) : 327 - 332
  • [2] Apoptosis induced by niacin-related compounds in HL-60 cells
    Ogata, S
    Takeuchi, M
    Okumura, K
    Taguchi, H
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1998, 62 (12) : 2351 - 2356
  • [3] Hydroquinone-induced apoptosis in HL-60 cells
    Terasaka, H
    Morshed, SRMD
    Hashimoto, K
    Sakagami, H
    Fujisawa, S
    ANTICANCER RESEARCH, 2005, 25 (1A) : 161 - 170
  • [4] Antimycin A-induced apoptosis of HL-60 cells
    King, MA
    Radicchi-Mastroianni, MA
    CYTOMETRY, 2002, 49 (03): : 106 - 112
  • [5] Amino acid utilization during apoptosis in HL-60 cells
    Sakagami, H
    Yokote, Y
    Kochi, M
    Hara, EI
    Akahane, K
    ANTICANCER RESEARCH, 1999, 19 (1A) : 329 - 332
  • [6] Quercetin induced apoptosis in human leukemia HL-60 cells
    Xiao, D
    Zhu, SP
    Gu, ZL
    ACTA PHARMACOLOGICA SINICA, 1997, 18 (03): : 280 - 283
  • [7] Securinine induced apoptosis in human leukemia HL-60 cells
    Dong, NZ
    Gu, ZL
    Chou, WH
    Kwok, CY
    ACTA PHARMACOLOGICA SINICA, 1999, 20 (03): : 267 - 270
  • [8] Apoptosis and cytolysis induced by giganteosides and hederacolchisides in HL-60 cells
    Gerkens, Pascal C.
    Dobson, Rowan
    Tabatadze, Nino
    Mshviladzade, Vakhtang
    Elias, Riad
    Peulen, Olivier J.
    Jolois, Olivier M.
    De Pauw-Gillet, Marie-Claire A.
    ANTICANCER RESEARCH, 2007, 27 (4B) : 2529 - 2534
  • [9] Ethanol-induced apoptosis in human HL-60 cells
    Aroor, AR
    Baker, RC
    LIFE SCIENCES, 1997, 61 (23) : 2345 - 2350
  • [10] Sonodynamically induced apoptosis with porfimer sodium in HL-60 cells
    Yumita, Nagahiko
    Han, Oing-Song
    Umemura, Shin-Ichiro
    ANTI-CANCER DRUGS, 2007, 18 (10) : 1149 - 1156
12345