Pathogenesis-based new perspectives of management of ANCA-associated vasculitis

被引：7

作者：

Sciascia, Savino ^{[1
,2
]}

Ponticelli, Claudio

Roccatello, Dario ^{[1
,2
]}

机构：

[1] Univ Turin, CMID Nephrol & Dialysis Unit, Ctr Res Immunopathol & Rare Dis,Dept Clin & Biol, Coordinating Ctr Network Rare Dis Piedmont & Aost, Turin, Italy

[2] S Giovanni Bosco Hub Hosp, Piazza Donatore Sangue 3, I-10154 Turin, Italy

来源：

AUTOIMMUNITY REVIEWS | 2022年 / 21卷 / 03期

关键词：

ANCA-associated vasculitis; Rituximab; Complement; ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; ALTERNATIVE COMPLEMENT PATHWAY; WEGENERS-GRANULOMATOSIS; MICROSCOPIC POLYANGIITIS; PLASMA-EXCHANGE; C5A RECEPTOR; NEUTROPHILS; ACTIVATION; GLOMERULONEPHRITIS; AUTOANTIBODIES;

D O I：

10.1016/j.autrev.2021.103030

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

While the pathogenesis of anti-neutrophil cytoplasmic autoantibody associated vasculitis (AAV) is still not fully elucidated, there is a mounting evidence that the process is initiated by inflammation and activation of innate immunity in the presence of predisposing factors, innate immunity abnormalities, aberrant responses of the adaptive immune system, and complement system activation. Biologics targeting inflammation-related molecules in the immune system have been explored to treat AVV, and these treatments have provided revolutionary advances. When focusing on the pathogenic mechanisms of AVV, this review presents the new findings regarding novel therapeutic approaches for the management of these conditions.

引用

页数：8

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