Prognostic Significance of Transient Receptor Potential Vanilloid Type 1 (TRPV1) and Phosphatase and Tension Homolog (PTEN) in Epithelial Ovarian Cancer

被引：12
作者：
Han, Gwan Hee [1 ,2 ]
Chay, Doo Byung [1 ]
Nam, Sanghee [3 ]
Cho, Hanbyoul [1 ,4 ]
Chung, Joon-Yong [4 ]
Kim, Jae-Hoon [1 ]
机构：
[1] Yonsei Univ, Dept Obstet & Gynecol, Coll Med, Seoul, South Korea
[2] Kyung Hee Univ Hosp Gangdong, Dept Obstet & Gynecol, Seoul, South Korea
[3] Gangnam Severance Hosp, Dept Obstet & Gynecol, Seoul, South Korea
[4] NCI, Expt Pathol Lab, Lab Pathol, Ctr Canc Res,NIH, Bethesda, MD 20892 USA
来源：
CANCER GENOMICS & PROTEOMICS | 2020年 / 17卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
Epithelial ovarian cancer; tumor marker; TRPV1; PTEN; EXPRESSION; ACTIVATION; CAPSAICIN; CELLS; APOPTOSIS; ESTROGEN; HER-2/NEU; MUTATIONS; CARCINOMA; CHANNELS;
D O I：
10.21873/cgp.20191
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Transient receptor potential vanilloid type 1 (TRPV1) has been studied in human malignancies, but has not been studied in epithelial ovarian cancer (LOC). We, therefore, investigated the significance of TRPV1 and correlation with phosphatase and tension homolog (PTEN) in EOC. Materials and Methods: Immunohistochemical analyses for TRPV1 and PTEN were performed using a tissue microarray. Moreover, the role of TRPV1 in cell growth was assessed in a EOC cell line. Results: High TRPV1 expression and the combination of high TRPV1 and low PTEN expression were an independent prognostic factor for overall survival and disease free survival. In vitro results demonstrated that knockdown of TRPV1 was associated with decreased cell viability and colony formation. Conclusion: There is a strong association between TRPV1 and PTEN and the combination of TRPV1 and PTEN is a strong indicator of prognostic predictor in EOC.
引用
收藏
页码：309 / 319
页数：11
相关论文
共 34 条
[21]   Targeting the PI3K/PTEN/AKT/mTOR Pathway in Treatment of Sarcoma Cell Lines [J].
Lim, Hui Jun ;
Wang, Xiaochun ;
Crowe, Philip ;
Goldstein, David ;
Yang, Jia-Lin .
ANTICANCER RESEARCH, 2016, 36 (11) :5765-5771
[22]   Activation of PTEN by inhibition of TRPV4 suppresses colon cancer development [J].
Liu, Xiaoyu ;
Zhang, Peng ;
Xie, Chuanming ;
Sham, Kathy W. Y. ;
Ng, Simon S. M. ;
Chen, Yangchao ;
Cheng, Christopher H. K. .
CELL DEATH & DISEASE, 2019, 10 (6)
[23]   High expression of vanilloid receptor-1 is associated with better prognosis of patients with hepatocellular carcinoma [J].
Miao, Xiongying ;
Liu, Guoxing ;
Xu, Xundi ;
Xie, Chengzhi ;
Sun, Fadi ;
Yang, Yaohui ;
Zhang, Tao ;
Hua, Songwen ;
Fan, Wentao ;
Li, Qinglong ;
Huang, Shengfu ;
Wang, Qunwei ;
Liu, Guoli ;
Zhong, Dewu .
CANCER GENETICS AND CYTOGENETICS, 2008, 186 (01) :25-32
[24]   Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation [J].
Morelli, Maria Beatrice ;
Amantini, Consuelo ;
Nabissi, Massimo ;
Liberati, Sonia ;
Cardinali, Claudio ;
Farfariello, Valerio ;
Tomassoni, Daniele ;
Quaglia, Wilma ;
Piergentili, Alessandro ;
Bonifazi, Alessandro ;
Del Bello, Fabio ;
Santoni, Matteo ;
Mammana, Gabriele ;
Servi, Lucilla ;
Filosa, Alessandra ;
Gismondi, Angela ;
Santoni, Giorgio .
BMC CANCER, 2014, 14
[25]  
Park YR, 2016, CANCER GENOM PROTEOM, V13, P83
[26]   The Immunohistochemical Expression of the Oestrogen Receptor (ER), HER-2/NEU and Cytokeratin 8/18 and 5/6 in Invasive Breast Carcinoma [J].
Rattan, Bharti ;
Manjari, Mridu ;
Kahlon, S. K. ;
Kalra, Nikita ;
Bhalla, Amarpreet ;
Paul, Surinder .
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2012, 6 (09) :1495-1498
[27]   High intraepithelial expression of estrogen and progesterone receptors in the transformation zone of the uterine cervix [J].
Remoue, F ;
Jacobs, N ;
Miot, V ;
Boniver, J ;
Delvenne, P .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2003, 189 (06) :1660-1665
[28]  
Ross JS, 1999, AM J CLIN PATHOL, V112, pS53
[29]   Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors [J].
Sung, Bokyung ;
Prasad, Sahdeo ;
Ravindran, Jayaraj ;
Yadav, Vivek R. ;
Aggarwal, Bharat B. .
FREE RADICAL BIOLOGY AND MEDICINE, 2012, 53 (10) :1977-1987
[30]   The activation of transient receptor potential vanilloid receptor subtype 1 by capsaicin without extracellular Ca2+ is involved in the mechanism of distinct substance P release in cultured rat dorsal root ganglion neurons [J].
Tang, He-Bin ;
Nakata, Yoshihiro .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2008, 377 (4-6) :325-332
1234