Prognostic Significance of Transient Receptor Potential Vanilloid Type 1 (TRPV1) and Phosphatase and Tension Homolog (PTEN) in Epithelial Ovarian Cancer

被引：12

作者：

Han, Gwan Hee ^{[1
,2
]}

Chay, Doo Byung ^{[1
]}

Nam, Sanghee ^{[3
]}

Cho, Hanbyoul ^{[1
,4
]}

Chung, Joon-Yong ^{[4
]}

Kim, Jae-Hoon ^{[1
]}

机构：

[1] Yonsei Univ, Dept Obstet & Gynecol, Coll Med, Seoul, South Korea

[2] Kyung Hee Univ Hosp Gangdong, Dept Obstet & Gynecol, Seoul, South Korea

[3] Gangnam Severance Hosp, Dept Obstet & Gynecol, Seoul, South Korea

[4] NCI, Expt Pathol Lab, Lab Pathol, Ctr Canc Res,NIH, Bethesda, MD 20892 USA

来源：

CANCER GENOMICS & PROTEOMICS | 2020年 / 17卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Epithelial ovarian cancer; tumor marker; TRPV1; PTEN; EXPRESSION; ACTIVATION; CAPSAICIN; CELLS; APOPTOSIS; ESTROGEN; HER-2/NEU; MUTATIONS; CARCINOMA; CHANNELS;

D O I：

10.21873/cgp.20191

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Transient receptor potential vanilloid type 1 (TRPV1) has been studied in human malignancies, but has not been studied in epithelial ovarian cancer (LOC). We, therefore, investigated the significance of TRPV1 and correlation with phosphatase and tension homolog (PTEN) in EOC. Materials and Methods: Immunohistochemical analyses for TRPV1 and PTEN were performed using a tissue microarray. Moreover, the role of TRPV1 in cell growth was assessed in a EOC cell line. Results: High TRPV1 expression and the combination of high TRPV1 and low PTEN expression were an independent prognostic factor for overall survival and disease free survival. In vitro results demonstrated that knockdown of TRPV1 was associated with decreased cell viability and colony formation. Conclusion: There is a strong association between TRPV1 and PTEN and the combination of TRPV1 and PTEN is a strong indicator of prognostic predictor in EOC.

引用

页码：309 / 319

页数：11

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