Picoliter Drop-On-Demand Dispensing for Multiplex Liquid Cell Transmission Electron Microscopy

被引：11

作者：

Patterson, Joseph P. ^{[1
]}

Parent, Lucas R. ^{[1
]}

Cantlon, Joshua ^{[2
]}

Eickhoff, Holger ^{[2
]}

Bared, Guido ^{[2
]}

Evans, James E. ^{[3
]}

Gianneschi, Nathan C. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] SCIENION AG, Volmerstr 7a, D-12489 Berlin, Germany

[3] Pacific Northwest Natl Lab, Environm Mol Sci Lab, 3335 Innovat Blvd, Richland, WA 99354 USA

来源：

MICROSCOPY AND MICROANALYSIS | 2016年 / 22卷 / 03期

关键词：

liquid cell transmission electron microscopy; TEM sample preparation; dispensing organic non-organic solutions; grid loading; NANOCRYSTAL GROWTH; BLOCK-COPOLYMERS; NUCLEATION; NANOPARTICLES; TECHNOLOGY; DEPOSITION; INTERFACE;

D O I：

10.1017/S1431927616000659

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Liquid cell transmission electron microscopy (LCTEM) provides a unique insight into the dynamics of nanomaterials in solution. Controlling the addition of multiple solutions to the liquid cell remains a key hurdle in our ability to increase throughput and to study processes dependent on solution mixing including chemical reactions. Here, we report that a piezo dispensing technique allows for mixing of multiple solutions directly within the viewing area. This technique permits deposition of 50 pL droplets of various aqueous solutions onto the liquid cell window, before assembly of the cell in a fully controlled manner. This proof-of-concept study highlights the great potential of picoliter dispensing in combination with LCTEM for observing nanoparticle mixing in the solution phase and the creation of chemical gradients.

引用

页码：507 / 514

页数：8

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