Synthesis, characterization and preliminary in vitro trypanocidal activity of N -aryl fluorinated hydroxylated-Schiff bases

被引：8

作者：

Avila-Sorrosa, Alcives ^{[1
]}

Bando-Vazquez, Alejandro Y. ^{[1
]}

Alvarez-Alvarez, Veronica ^{[1
]}

Suarez-Contreras, Erick ^{[2
]}

Nieto-Meneses, Rocio ^{[2
]}

Nogueda-Torres, Benjamin ^{[2
]}

Elena Vargas-Diaz, Maria ^{[1
]}

Diaz-Cedillo, Francisco ^{[1
]}

Reyes-Martinez, Reyna ^{[3
]}

Hernandez-Ortega, Simon ^{[4
]}

Morales-Morales, David ^{[4
]}

机构：

[1] Escuela Nacl Ciencias Biol, Inst Politecn Nacl, Dept Quim Organ, Carpio & Plan de Ayala S-N, Mexico City 11340, DF, Mexico

[2] Escuela Nacl Ciencias Biol, Inst Politecn Nacl, Dept Parasitol, Carpio & Plan de Ayala S-N, Mexico City 11340, DF, Mexico

[3] Univ Autonoma Chihuahua, Fac Ciencias Quim, Chihuahua, Mexico

[4] Univ Nacl Autonoma Mexico, Inst Quim, Circuito Exterior S-N,Ciudad Univ, Mexico City 04510, DF, Mexico

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2020年 / 1218卷

关键词：

BIOLOGICAL-ACTIVITY; CHEMISTRY;

D O I：

10.1016/j.molstruc.2020.128520

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A series of N-arylfluorinated hydroxylated-Schiff bases were synthesized in a facile and high yield manner. The compounds were fully characterized including the unequivocal determination of the structure of two derivatives (2 and 4) by single crystal X-ray diffraction analysis. Preliminary in vitro antiparasitic activity against an endemic Trypanosoma cruzi strains in Mexico (NINOA) showed these compunds to have better trypanocidal activity compared to the reference drugs Nifurtimox (Nfx) and Benznidazole (Bnz). © 2020 Elsevier B.V.

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页数：10

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