Clinical trials in acute heart failure: simpler solutions to complex problems. Consensus document arising from a European Society of Cardiology cardiovascular round-table think tank on acute heart failure, 12 May 2009

被引：30

作者：

McDonagh, Theresa A. ^{[1
]}

Komajda, Michel ^{[2
]}

Maggioni, Aldo P. ^{[3
]}

Zannad, Faiez ^{[4
]}

Gheorghiade, Mihai ^{[5
]}

Metra, Marco ^{[6
]}

Dargie, Henry J. ^{[7
]}

机构：

[1] Kings Coll Hosp London, Dept Cardiol, London SE5 9RS, England

[2] CHU Pitie Salpetriere, Inst Cardiol, Paris, France

[3] ANMCO Res Ctr, Florence, Italy

[4] Nancy Univ, Dept Cardiol, Nancy, France

[5] Northwestern Univ, Ctr Cardiovasc Innovat, Chicago, IL 60611 USA

[6] Univ Brescia, Sect Cardiovasc Dis, I-25121 Brescia, Italy

[7] Western Infirm & Associated Hosp, Glasgow G11 6NT, Lanark, Scotland

来源：

EUROPEAN JOURNAL OF HEART FAILURE | 2011年 / 13卷 / 12期

关键词：

Acute heart failure; Clinical trials; LEFT-VENTRICULAR DYSFUNCTION; RANDOMIZED CONTROLLED-TRIAL; INTENSIVE-CARE MEDICINE; IN-HOSPITAL MORTALITY; NATRIURETIC PEPTIDE; RISK STRATIFICATION; MYOCARDIAL-INFARCTION; RENAL-FUNCTION; DOUBLE-BLIND; CD-NP;

D O I：

10.1093/eurjhf/hfr126

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This European consensus document aims to identify the main reasons for the apparent lack of progress in the introduction of new medicines for acute heart failure. Relevant issues include not only the heterogeneity of the patient group but also the pharmacology of the medicines themselves and the design of the trials. Above all, this document attempts to provide some pragmatic solutions to this complex syndrome to simplify the execution of meaningful therapeutic endeavours in this area of undoubted unmet clinical need in the future.

引用

页码：1253 / 1260

页数：8

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