Role for proteases and HLA-G in the pathogenicity of influenza A viruses

被引:14
作者
Foucault, Marie-Laure [1 ]
Moules, Vincent [1 ]
Rosa-Calatrava, Manuel [1 ]
Riteau, Beatrice [1 ,2 ]
机构
[1] Univ Lyon 1, CNRS, Fac Med RTH Laennec, FRE Virpath 3011, F-69008 Lyon, France
[2] INRA, Dept Sante Anim, Tours, France
关键词
Influenza virus; HLA-G; Proteases-activated receptors; Inflammation; Host-virus relation; Therapeutic; PROTEINASE-ACTIVATED RECEPTOR-2; LUNG EPITHELIAL-CELLS; G EXPRESSION; PROTEOLYTIC ACTIVATION; RESPIRATORY EPITHELIUM; SERINE PROTEASES; PROTECTIVE ROLE; ANNEXIN-II; HEMAGGLUTININ; CLEAVAGE;
D O I
10.1016/j.jcv.2011.04.013
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Influenza is one of the most common infectious diseases in humans occurring as seasonal epidemic and sporadic pandemic outbreaks. The ongoing infections of humans with avian H5N1 influenza A viruses (IAV) and the past 2009 pandemic caused by the quadruple human/avian/swine reassortant (H1N1) virus highlights the permanent threat caused by these viruses. This review aims to describe the interaction between the virus and the host, with a particular focus on the role of proteases and HLA-G in the pathogenicity of influenza viruses. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:155 / 159
页数:5
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