Solitary Fibrous Tumor of the Central Nervous System: A 15-year Literature Survey of 220 Cases (August 1996-July 2011)

被引:104
作者
Bisceglia, Michele [1 ]
Galliani, Carlos [4 ]
Giannatempo, Giuseppe [2 ]
Lauriola, Walter [2 ]
Bianco, Mario [3 ]
D'Angelo, Vincenzo [3 ]
Pizzolitto, Stefano [5 ]
Vita, Giulia [6 ]
Pasquinelli, Gianandrea [7 ]
Magro, Gaetano [8 ]
Ben Dor, David [9 ]
机构
[1] IRCSS Casa Sollievo Sofferenza Hosp, Dept Pathol, Div Anat Pathol, I-71013 San Giovanni Rotondo, FG, Italy
[2] IRCSS Casa Sollievo Sofferenza Hosp, Dept Radiol, I-71013 San Giovanni Rotondo, FG, Italy
[3] IRCSS Casa Sollievo Sofferenza Hosp, Dept Neurosci, I-71013 San Giovanni Rotondo, FG, Italy
[4] Cook Childrens Med Ctr, Dept Pathol, Ft Worth, TX USA
[5] S Maria della Misericordia Gen Hosp, Dept Pathol & Lab Med, Udine, Italy
[6] Referral Canc Ctr Basilicata, Anat Pathol Unit, IRCCS CROB, Rionero In Vulture, PZ, Italy
[7] Univ Bologna, Policlin S Orsola, Dept Hematol Oncol & Clin Pathol, Bologna, Italy
[8] Univ Catania, Dept Pathol, Catania, Italy
[9] Barzilai Govt Hosp, Dept Pathol, Ashqelon, Israel
关键词
solitary fibrous tumor; meninges; brain tumor; spinal cord tumor; central nervous system; CD34; MIMICKING PITUITARY-ADENOMA; RIBOSOME-LAMELLA COMPLEX; SPINDLE-CELL TUMORS; SOFT-TISSUE; SPINAL-CORD; DIFFERENTIAL-DIAGNOSIS; CD34; IMMUNOREACTIVITY; IMAGING FEATURES; PERIPHERAL-NERVE; CHORDOID GLIOMA;
D O I
10.1097/PAP.0b013e318229c004
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
We reviewed the world literature on solitary fibrous tumors of the central nervous system from August 1996 to July 2011, focusing on both clinicopathological features and diagnostic findings. The anatomical distribution of the 220 cases reported so far reveals that most are intracranial and just over one-fifth are intraspinal. In decreasing frequency, intracranial tumors involve the supratentorial and infratentorial compartments, the pontocerebellar angle, the sellar and parasellar regions, and the cranial nerves. Intraspinal tumors are mainly located in the thoracic and cervical segments. Although most solitary fibrous tumors of the central nervous system are dural based, a small subset presents as subpial, intraparenchymal, intraventricular, or as tumors involving the nerve rootlets with no dural connection. Preoperative imaging and intraoperative findings suggest meningioma, schwannoma or neurofibroma, hemangiopericytoma, or pituitary tumors. Immunohistochemistry is critical to establish a definitive histopathological diagnosis. Vimentin, CD34, BCL2, and CD99 are the most consistently positive markers. The usual histologic type generally behaves in a benign manner if complete removal is achieved. Recurrence is anticipated when resection is subtotal or when the tumor exhibits atypical histology. The proliferative index as assessed by MIB1 labeling is of prognostic significance. Occasionally, tumors featuring conventional morphology may recur, perhaps because of minimal residual disease left behind during surgical extirpation. Rare extracranial metastases and tumor-related deaths are on record. Surgery is the treatment of choice. Stereotactic and external beam radiation therapy may be indicated for postsurgical tumor remnants and for unresectable recurrences. Long-term active surveillance of the patients is mandatory.
引用
收藏
页码:356 / 392
页数:37
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