To assess the levels of zinc in serum and changes in the lens of diabetic and senile cataract patients

被引：0
作者：
Rahim, Amena [1 ]
Iqbal, Khadija [2 ]
机构：
[1] Islamic Int Med Coll, Dept Biochem, Rawalpindi, Pakistan
[2] Islamic Int Med Coll, Dept Anat, Rawalpindi, Pakistan
来源：
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION | 2011年 / 61卷 / 09期
关键词：
Diabetes; Senile; Cataract; Zinc; RISK;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To assess the levels of zinc in serum and changes in the lens of diabetic and senile cataract patients Methods: A comparative cross sectional study was done at LRBT (Layton Rehmatullah Benevolent Trust) free eye hospital Mandra from July 2010 to August 2010. Twenty Type 2 diabetic patients with cataracts and 20 patients without diabetes of senile cataract were included in the study. Glucose levels were determined by glucose oxidase method and zinc levels measured by colorimeteric method (RANDOX). Results: The statistical analysis showed a statistically significant decrease in zinc levels in diabetic patients with cataract when compared to individuals with senile cataract (P <0.05). In senile lenses multilayering of cells, wrinkling of the lens capsule, and apoptotic cell death were seen, but in diabetic lenses number of cells decreased and cells were smaller as compared to senile lenses. The results were not statistically significant P >0.05. Conclusion: Our findings in this study show a relationship between zinc deficiency and increased occurrence of cataract among people with diabetes.
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页码：853 / 855
页数：3
相关论文
共 16 条
  • [1] ASONYE CC, 2004, MIDWESTERNNIGERIA CA, P4
  • [2] Behndig A, 2001, INVEST OPHTH VIS SCI, V42, P2293
  • [3] DORAIRAJ SJ, 2002, J ANAT SOC INDIA, V51, P14
  • [4] Zinc and the eye
    Grahn, BH
    Paterson, PG
    Gottschall-Pass, KT
    Zhang, Z
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2001, 20 (02) : 106 - 118
  • [5] LENSFIBRE DEGENERATION AT CATARACT LENSES - A LM, SEM AND TEM INVESTIGATION
    KALICHARAN, D
    JONGEBLOED, WL
    WORST, JGF
    [J]. DOCUMENTA OPHTHALMOLOGICA, 1993, 85 (01) : 77 - 85
  • [6] Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study
    Kang, Daehee
    Lee, Kyoung-Mu
    Park, Sue Kyung
    Berndt, Sonja I.
    Peters, Ulrike
    Reding, Douglas
    Chatterjee, Nilanjan
    Welch, Robert
    Chanock, Stephen
    Huang, Wen-Yi
    Hayes, Richard B.
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (08) : 1581 - 1586
  • [7] A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss - AREDS Report No. 8
    Kassoff, A
    Kassoff, J
    Buehler, J
    Eglow, M
    Kaufman, F
    Mehu, M
    Kieval, S
    Mairs, M
    Graig, B
    Quattrocchi, A
    Jones, D
    Locatelli, J
    Ruby, A
    Capone, A
    Garretson, B
    Hassan, T
    Trese, MT
    Williams, GA
    Regan, V
    Manatrey, P
    Streasick, P
    Szydlowski, L
    McIver, F
    Bridges, C
    Stanley, C
    Cumming, K
    Lewis, B
    Zajechowski, M
    Margherio, RR
    Cox, MS
    Camille, J
    Falk, R
    Siedlak, P
    Neubert, C
    Klein, ML
    Stout, JT
    O'Malley, A
    Lauer, AK
    Robertson, JE
    Wilson, DJ
    Beardsley, C
    Anderson, H
    Wallace, P
    Smith, G
    Howard, S
    Dreyer, RF
    Ma, C
    Chenoweth, RG
    Zilis, JD
    Johnson, M
    [J]. ARCHIVES OF OPHTHALMOLOGY, 2001, 119 (10) : 1417 - 1436
  • [8] Mirsamadi Mansour, 2004, Int J Med Sci, V1, P165
  • [9] Enhanced Diabetes-Induced Cataract in Copper-Zinc Superoxide Dismutase-Null Mice
    Olofsson, Eva M.
    Marklund, Stefan L.
    Behndig, Anders
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2009, 50 (06) : 2913 - 2918
  • [10] Pendergrass WR, 2006, MOL VIS, V12, P712
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