Spatial performance correlates with long-term potentiation of the dentate gyrus but not of the CA1 region in rats with fimbria-fornix lesions

被引：19

作者：

Nakao, K ^{[1
]}

Ikegaya, Y ^{[1
]}

Yamada, MK ^{[1
]}

Nishiyama, N ^{[1
]}

Matsuki, N ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Chem Pharmacol Lab, Tokyo 1130033, Japan

来源：

NEUROSCIENCE LETTERS | 2001年 / 307卷 / 03期

关键词：

long-term potentiation; fimbria-fornix; CA1; dentate gyrus; learning and memory; spontaneous alternation behavior; rat;

D O I：

10.1016/S0304-3940(01)01961-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although hippocampal long-term potentiation (LTP) is generally assumed to be a cellular mechanism of learning and memory, there has not been definitive evidence for this hypothesis. In the present study, therefore, we addressed the possible relationship between spatial learning ability and LTP by using rats with bilateral fimbria-fornix lesions. The animals were tested for spatial performance in spontaneous alternation behaviors with further in vivo investigation of LTP. The behavioral parameters of spatial memory showed a significant correlation with LTP in the dentate gyrus, but we found no evidence for a linkage with LTP in the CA1 region. Thus, LTP. in the dentate gyrus may be important for spatial cognitive ability. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：159 / 162

页数：4

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