Benzodiazepine receptor (BZR) ligands.: 6 new 3-(2-,3- or 4-substituted benzyloxycarbonyl) derivatives of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide:: Receptor affinity and in vivo testing

The synthesis of new 3-(2-, 3- or 4-substituted benzyloxycarbonyl) derivatives of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide and their binding affinities at the central benzodiazepine receptor (BZR) are reported. Among the synthesized compounds, the eater 12, having the best affinity (K-i = 1 nM), and compounds 5 and 10 were chosen for in vivo testing.