Benzodiazepine receptor (BZR) ligands.: 6 new 3-(2-,3- or 4-substituted benzyloxycarbonyl) derivatives of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide:: Receptor affinity and in vivo testing

被引：0

作者：

Costanzo, A

Guerrini, G

Ciciani, G

Bruni, F

Costagli, C

Selleri, S

Costa, B

Martini, C

Aiello, PM

机构：

[1] Univ Florence, Dipartimento Sci Farmaceut, I-50121 Florence, Italy

[2] Univ Pisa, Dipartimento Psichiatria Neurobiol Farmacol & Bio, I-56126 Pisa, Italy

[3] Univ Florence, Dipartimento Farmacol Preclin & Clin Aiazzi Manci, I-50139 Florence, Italy

来源：

MEDICINAL CHEMISTRY RESEARCH | 2001年 / 10卷 / 06期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of new 3-(2-, 3- or 4-substituted benzyloxycarbonyl) derivatives of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide and their binding affinities at the central benzodiazepine receptor (BZR) are reported. Among the synthesized compounds, the eater 12, having the best affinity (K-i = 1 nM), and compounds 5 and 10 were chosen for in vivo testing.

引用

页码：366 / 377

页数：12

共 15 条

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