Continuous gas/liquid-liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination

被引：31

作者：

Breen, Jessica R.

Sandford, Graham ^{[1
]}

Yufit, Dmitrii S. ^{[1
]}

Howard, Judith A. K. ^{[1
]}

Fray, Jonathan ^{[2
]}

Patel, Bhairavi ^{[2
]}

机构：

[1] Univ Durham, Dept Chem, Chem Crystallog Grp, Durham DH1 3LE, England

[2] Pfizer Global Res & Dev, Sandwich CT13 9NJ, Kent, England

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 7卷

基金：

英国工程与自然科学研究理事会;

关键词：

continuous flow reactions; fluorine; fluoropyrazole; gas-liquid flow reactor; selective direct fluorination; ELEMENTAL FLUORINE; MICROREACTORS; QUINOLINE;

D O I：

10.3762/bjoc.7.120

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Fluoropyrazole systems may be prepared by a single, sequential telescoped two-step continuous gas/liquid-liquid/liquid flow process from diketone, fluorine gas and hydrazine starting materials.

引用

页码：1048 / 1054

页数：7

共 31 条

[1]

BAASNER B, 2000, HOUBENWEYL ORGANOF A, V10

[2]

Banks R. E., 1994, ORGANOFLUORINE CHEM

[3]

BREEN JR, UNPUB

[4] Process development of voriconazole: A novel broad-spectrum triazole antifungal agent [J].