The prognostic impact of age in different molecular subtypes of breast cancer

被引:75
作者
Liedtke, Cornelia [1 ]
Rody, Achim [1 ]
Gluz, Oleg [2 ]
Baumann, Kristin [1 ]
Beyer, Daniel [1 ]
Kohls, Eva-Beatrice [1 ]
Lausen, Kerstin [1 ]
Hanker, Lars [1 ]
Holtrich, Uwe [3 ]
Becker, Sven [3 ]
Karn, Thomas [3 ]
机构
[1] Univ Hosp Schleswig Holstein, Dept Obstet & Gynecol, D-23538 Lubeck, Germany
[2] Westgerman Studygrp, D-41061 Monchengladbach, Germany
[3] Goethe Univ Frankfurt, Dept Obstet & Gynecol, D-60590 Frankfurt, Germany
关键词
Triple negative breast cancer; Age at diagnosis; Gene expression analysis; YOUNG; SIGNATURE; PATTERNS; THERAPY; BIOLOGY; MARKER;
D O I
10.1007/s10549-015-3491-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Breast cancer is a heterogeneous entity composed of distinct molecular subgroups with different molecular and clinical features. We analyzed the association between molecular breast cancer subgroups, age at diagnosis, and prognosis in a compilation of publicly available gene expression datasets. Affymetrix gene expression data (U133A or U133Plus2.0 arrays) of 4467 breast cancers from 40 datasets were compiled and homogenized. Breast cancer subgroups were defined based on expression of ESR1, PR, HER2, and Ki67. Event-free survival was calculated as recurrence-free survival or distant metastasis-free survival if recurrence-free survival was not available. Young age at diagnosis is associated with higher frequency of triple negative and HER2 subtypes and lower frequency of luminal A breast cancers. The 5-year event-free survival rates of patients aged less than 40, between 40 and 50, and > 50 years were 54.3 +/- A 3.5, 68.5 +/- A 1.9, and 70.4 +/- A 1.3 %, respectively. When controlling for breast cancer subtype, we found that age < 40 years remained significantly associated with poor prognosis in triple negative breast cancer. The effect was modest in luminal tumors and not found in HER2 subtype. Both subtypes and age retained their significances in multivariate analysis. Association of age at diagnosis with molecular breast cancer subtype contributes to its important role as prognostic factor among patients with breast cancer. Still, within the group of triple negative breast cancer, young age < 40 years has a significant prognostic value which was retained in multivariate analysis.
引用
收藏
页码:667 / 673
页数:7
相关论文
共 36 条
  • [1] Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression
    Anders, Carey K.
    Hsu, David S.
    Broadwater, Gloria
    Acharya, Chaitanya R.
    Foekens, John A.
    Zhang, Yi
    Wang, Yixin
    Marcom, P. Kelly
    Marks, Jeffrey R.
    Febbo, Phillip G.
    Nevins, Joseph R.
    Potti, Anil
    Blackwell, Kimberly L.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (20) : 3324 - 3330
  • [2] Breast Carcinomas Arising at a Young Age: Unique Biology or a Surrogate for Aggressive Intrinsic Subtypes?
    Anders, Carey K.
    Fan, Cheng
    Parker, Joel S.
    Carey, Lisa A.
    Blackwell, Kimberly L.
    Klauber-DeMore, Nancy
    Perou, Charles M.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (01) : E18 - E20
  • [3] How Many Etiological Subtypes of Breast Cancer: Two, Three, Four, Or More?
    Anderson, William F.
    Rosenberg, Philip S.
    Prat, Aleix
    Perou, Charles M.
    Sherman, Mark E.
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2014, 106 (08):
  • [4] Elucidating Prognosis and Biology of Breast Cancer Arising in Young Women Using Gene Expression Profiling
    Azim, Hatem A., Jr.
    Michiels, Stefan
    Bedard, Philippe L.
    Singhal, Sandeep K.
    Criscitiello, Carmen
    Ignatiadis, Michail
    Haibe-Kains, Benjamin
    Piccart, Martine J.
    Sotiriou, Christos
    Loi, Sherene
    [J]. CLINICAL CANCER RESEARCH, 2012, 18 (05) : 1341 - 1351
  • [5] Are there changes in characteristics and therapy of young patients with early-onset breast cancer in Germany over the last decade?
    Banz-Jansen, Constanze
    Heinrichs, Alessa
    Hedderich, Marianne
    Waldmann, Annika
    Wedel, Berit
    Mebes, Imke
    Diedrich, Klaus
    Rody, Achim
    Fischer, Dorothea
    [J]. ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2013, 288 (02) : 379 - 383
  • [6] The Impact of Age on Outcome in Early-Stage Breast Cancer
    Beadle, Beth M.
    Woodward, Wendy A.
    Buchholz, Thomas A.
    [J]. SEMINARS IN RADIATION ONCOLOGY, 2011, 21 (01) : 26 - 34
  • [7] Triple-negative breast cancer: disease entity or title of convenience?
    Carey, Lisa
    Winer, Eric
    Viale, Giuseppe
    Cameron, David
    Gianni, Luca
    [J]. NATURE REVIEWS CLINICAL ONCOLOGY, 2010, 7 (12) : 683 - 692
  • [8] CORRELATIONS BETWEEN ESTROGEN-RECEPTOR, PROGESTERONE-RECEPTOR, AND PATIENT CHARACTERISTICS IN HUMAN-BREAST CANCER
    CLARK, GM
    OSBORNE, CK
    MCGUIRE, WL
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1984, 2 (10) : 1102 - 1109
  • [9] Age-Specific Gene Expression Signatures for Breast Tumors and Cross-Species Conserved Potential Cancer Progression Markers in Young Women
    Colak, Dilek
    Nofal, Asmaa
    AlBakheet, AlBandary
    Nirmal, Maimoona
    Jeprel, Hatim
    Eldali, Abdelmoneim
    AL-Tweigeri, Taher
    Tulbah, Asma
    Ajarim, Dahish
    Al Malik, Osama
    Inan, Mehmet S.
    Kaya, Namik
    Park, Ben H.
    Bin Amer, Suad M.
    [J]. PLOS ONE, 2013, 8 (05):
  • [10] A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients
    Dai, HY
    van't Veer, L
    Lamb, J
    He, YD
    Mao, M
    Fine, BM
    Bernards, R
    de Vijver, MV
    Deutsch, P
    Sachs, A
    Stoughton, R
    Friend, S
    [J]. CANCER RESEARCH, 2005, 65 (10) : 4059 - 4066