Genetic diversity and population structure of genes encoding vaccine candidate antigens of Plasmodium vivax

被引：42
作者：
Chenet, Stella M. [1 ,2 ,3 ]
Tapia, Lorena L. [1 ]
Escalante, Ananias A. [2 ,3 ]
Durand, Salomon [1 ]
Lucas, Carmen [1 ]
Bacon, David J. [1 ,4 ]
机构：
[1] Naval Med Res Unit 6, Parasitol Program, Lima, Peru
[2] Arizona State Univ, Sch Life Sci, Tempe, AZ USA
[3] Arizona State Univ, Ctr Evolutionary Med & Informat, Biodesign Inst, Tempe, AZ USA
[4] USN, Res Lab, Washington, DC 20375 USA
来源：
MALARIA JOURNAL | 2012年 / 11卷
关键词：
Malaria; Plasmodium vivax; Vaccine candidates; Haplotypes; CIRCUMSPOROZOITE PROTEIN GENE; HUMAN MALARIA PARASITE; DUFFY BINDING-PROTEIN; NATURAL-SELECTION; FALCIPARUM; EFFICACY; SEQUENCE; IMMUNOGENICITY; POLYMORPHISM; EPITOPES;
D O I：
10.1186/1475-2875-11-68
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Background: A major concern in malaria vaccine development is genetic polymorphisms typically observed among Plasmodium isolates in different geographical areas across the world. Highly polymorphic regions have been observed in Plasmodium falciparum and Plasmodium vivax antigenic surface proteins such as Circumsporozoite protein (CSP), Duffy-binding protein (DBP), Merozoite surface protein-1 (MSP-1), Apical membrane antigen-1 (AMA-1) and Thrombospondin related anonymous protein (TRAP). Methods: Genetic variability was assessed in important polymorphic regions of various vaccine candidate antigens in P. vivax among 106 isolates from the Amazon Region of Loreto, Peru. In addition, genetic diversity determined in Peruvian isolates was compared to population studies from various geographical locations worldwide. Results: The structured diversity found in P. vivax populations did not show a geographic pattern and haplotypes from all gene candidates were distributed worldwide. In addition, evidence of balancing selection was found in polymorphic regions of the trap, dbp and ama-1 genes. Conclusions: It is important to have a good representation of the haplotypes circulating worldwide when implementing a vaccine, regardless of the geographic region of deployment since selective pressure plays an important role in structuring antigen diversity.
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页数：11
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