Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility

被引:85
作者
Fleskens, Stijn [1 ]
Slootweg, Piet [2 ]
机构
[1] Radboud Univ Nijmegen Med Ctr, Dept Otolaryngol Head & Neck Surg, NL-6500 HB Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Pathol, NL-6500 HB Nijmegen, Netherlands
关键词
D O I
10.1186/1758-3284-1-11
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Grading of dysplasia, including head and neck lesions, continues to be a hotly debated subject. It is subjective and lacks intra- and inter-observer reproducibility due to the insufficiency of validated morphological criteria and the biological nature of dysplasia. Moreover, due to the absence of a consensus, several systems are currently employed. Objectives: The aims of this review are to: 1) Highlight the significance of dysplasia and the importance of a valid method for assessing precursor lesions of the head and neck. 2) Review the different histopathological classification systems for grading intraepithelial lesions of the head and neck. 3) Discuss and review quality requirements for these grading systems. Conclusion: Regarding the different classification systems, data concerning the WHO classification system are the most available in current literature. There is no simple relationship or overlapping between the classification systems. Further studies should be done to see whether other systems have advantages above the current WHO system and to discover indications that could lead to an universal classification system for intraepithelial lesions of the head and neck.
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页数:8
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