Chemerin regulates β-cell function in mice

被引：125

作者：

Takahashi, Michiko ^{[1
]}

Okimura, Yasuhiko ^{[2
]}

Iguchi, Genzo ^{[1
]}

Nishizawa, Hitoshi ^{[1
]}

Yamamoto, Masaaki ^{[1
]}

Suda, Kentaro ^{[1
]}

Kitazawa, Riko ^{[3
]}

Fujimoto, Wakako ^{[4
]}

Takahashi, Kenichi ^{[5
]}

Zolotaryov, Fyodor N. ^{[5
]}

Hong, Kyoung Su ^{[5
]}

Kiyonari, Hiroshi ^{[6
]}

Abe, Takaya ^{[6
]}

Kaji, Hidesuke ^{[7
]}

Kitazawa, Sohei ^{[8
]}

Kasuga, Masato ^{[9
]}

Chihara, Kazuo ^{[1
,10
]}

Takahashi, Yutaka ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Diabet & Endocrinol, Kobe, Hyogo 657, Japan

[2] Kobe Womens Univ, Dept Nutr & Food Sci, Kobe, Hyogo, Japan

[3] Kobe Univ, Grad Sch Med, Div Diagnost Mol Pathol, Kobe, Hyogo 657, Japan

[4] Kobe Univ, Grad Sch Med, Dept Physiol & Cell Biol, Div Cellular & Mol Med, Kobe, Hyogo 657, Japan

[5] JCR Pharmaceuticalc Co Ltd, Res Inst, Div Res, Kobe, Hyogo, Japan

[6] Riken Ctr Dev Biol CDB, Lab Anim Resources & Genet Engn, Kobe, Hyogo, Japan

[7] Univ Hyogo, Div Physiol Metab, Akashi, Hyogo, Japan

[8] Ehime Univ, Grad Sch Med, Div Mol Pathol, Matsuyama, Ehime 790, Japan

[9] Int Med Ctr Japan, Res Inst, Tokyo, Japan

[10] Hyogo Prefectural Kakogawa Med Ctr, Div Diabet & Endocrinol, Kakogawa, Japan

来源：

SCIENTIFIC REPORTS | 2011年 / 1卷

关键词：

INSULIN-SECRETION; ADIPOSE-TISSUE; GENE-EXPRESSION; GLUCOSE-UPTAKE; GROWTH; MAFA; INFLAMMATION; ADIPOKINE; ADIPOGENESIS; CHEMOKINES;

D O I：

10.1038/srep00123

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although various function of chemerin have been suggested, its physiological role remains to be elucidated. Here we show that chemerin-deficient mice are glucose intolerant irrespective of exhibiting reduced macrophage accumulation in adipose tissue. The glucose intolerance was mainly due to increased hepatic glucose production and impaired insulin secretion. Chemerin and its receptor ChemR23 were expressed in beta-cell. Studies using isolated islets and perfused pancreas revealed impaired glucose-dependent insulin secretion (GSIS) in chemerin-deficient mice. Conversely, chemerin transgenic mice revealed enhanced GSIS and improved glucose tolerance. Expression of MafA, a pivotal transcriptional factor for beta-cell function, was downregulated in chemerin-deficient islets and a chemerin-ablated beta-cell line and rescue of MafA expression restored GSIS, indicating that chemerin regulates beta-cell function via maintaining MafA expression. These results indicate that chemerin regulates beta-cell function and plays an important role in glucose homeostasis in a tissue-dependent manner.

引用

页数：10

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