Comparison of the IV pharmacokinetics in sheep of miconazole-cyclodextrin solutions and a micellar solution.

被引：27

作者：

Piel, G ^{[1
]}

Evrard, B ^{[1
]}

Van Hees, T ^{[1
]}

Delattre, L ^{[1
]}

机构：

[1] Univ Liege, Inst Pharm, Pharmaceut Technol Lab, B-4000 Liege 1, Belgium

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1999年 / 180卷 / 01期

关键词：

miconazole; cyclodextrin derivatives; intravenous pharmacokinetics; sheep;

D O I：

10.1016/S0378-5173(98)00403-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pharmacokinetics of miconazole were studied after intravenous administration to six sheep (4 mg/kg) of three aqueous solutions: a marketed micellar solution containing polyoxyl-35 castor oil (Daktarin IV (R)) was compared with two solutions both containing 50 mM lactic acid and a cyclodextrin derivative (100 mM HP-beta CD or 50 mM SBE7-beta CD). The aim of this work was to demonstrate that these cyclodextrin derivatives (CDs) have no effect on the pharmacokinetics of miconazole by comparison with the micellar solution. The plasma concentration time curves have shown that there is no significant difference between the three solutions. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：41 / 45

页数：5

共 19 条

[1]

BONONI LJ, 1995, Patent No. 5422347

[2]

BREWSTER ME, 1989, J PARENT SCI TECHN, V43, P262

[3] AN INTRAVENOUS TOXICITY STUDY OF 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN, A USEFUL DRUG SOLUBILIZER, IN RATS AND MONKEYS [J].

BREWSTER, ME ;

ESTES, KS ;

BODOR, N .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1990, 59 (03) :231-243

[4]

Hopkins CS, 1988, INTENSIVE THER CLIN, V9, P254

[5] QUANTITATIVE-DETERMINATION OF MICONAZOLE IN HUMAN-SERUM BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

HOSOTSUBO, H .

CHROMATOGRAPHIA, 1988, 25 (08) :717-720

[6] ANAPHYLACTOID REACTIONS ASSOCIATED WITH PARENTERAL CYCLOSPORINE USE - POSSIBLE ROLE OF CREMOPHOR-EL [J].

HOWRIE, DL ;

PTACHCINSKI, RJ ;

GRIFFITH, BP ;

HARDESTY, RJ ;

ROSENTHAL, JT ;

BURCKART, GJ ;

VENKATARAMANAN, R .

DRUG INTELLIGENCE & CLINICAL PHARMACY, 1985, 19 (06) :425-427

[7]

KAUFFMAN A, 1997, ADV PHARMACOL, V39, P147

[8]

MURA P, 1992, EUR J PHARM BIOPHARM, V38, P119

[9] FORMATION AND ANTIMYCOTIC EFFECT OF CYCLODEXTRIN INCLUSION COMPLEXES OF ECONAZOLE AND MICONAZOLE [J].

PEDERSEN, M ;

EDELSTEN, M ;

NIELSEN, VF ;

SCARPELLINI, A ;

SKYTTE, S ;

SLOT, C .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1993, 90 (03) :247-254

[10]

Pedersen M, 1993, PHARM ACTA HELV, V68, P43

← 1 2 →