Precision epidemiology for infectious disease control

被引：89

作者：

Ladner, Jason T. ^{[1
]}

Grubaugh, Nathan D. ^{[2
]}

Pybus, Oliver G. ^{[3
]}

Andersen, Kristian G. ^{[4
,5
]}

机构：

[1] No Arizona Univ, Pathogen & Microbiome Inst, Flagstaff, AZ USA

[2] Yale Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT USA

[3] Univ Oxford, Dept Zool, Oxford, England

[4] Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA

[5] Scripps Res Translat Inst, La Jolla, CA 92037 USA

来源：

NATURE MEDICINE | 2019年 / 25卷 / 02期

关键词：

EBOLA-VIRUS; REAL-TIME; GENOMIC EPIDEMIOLOGY; SEXUAL TRANSMISSION; ZIKA VIRUS; OUTBREAK; EVOLUTION; IMPACT; IMPLEMENTATION; CORONAVIRUS;

D O I：

10.1038/s41591-019-0345-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Advances in genomics and computing are transforming the capacity for the characterization of biological systems, and researchers are now poised for a precision-focused transformation in the way they prepare for, and respond to, infectious diseases. This includes the use of genome-based approaches to inform molecular diagnosis and individual-level treatment regimens. In addition, advances in the speed and granularity of pathogen genome generation have improved the capability to track and understand pathogen transmission, leading to potential improvements in the design and implementation of population-level public health interventions. In this Perspective, we outline several trends that are driving the development of precision epidemiology of infectious disease and their implications for scientists' ability to respond to outbreaks.

引用

页码：206 / 211

页数：6

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