Neuroprotective adaptations in hibernation: Therapeutic implications for ischemia-reperfusion, traumatic brain injury and neurodegenerative diseases

被引：120
作者：
Drew, KL
Rice, ME
Kuhn, TB
Smith, MA
机构：
[1] Univ Alaska, Inst Arctic Biol, Fairbanks, AK 99775 USA
[2] NYU, Sch Med, Dept Physiol, New York, NY USA
[3] NYU, Sch Med, Dept Neurosci & Neurosurg, New York, NY USA
[4] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2001年 / 31卷 / 05期
关键词：
Alzheimer disease; Arctic ground squirrel; oxidative stress; stroke; antioxidants; metabolic suppression; free radicals;
D O I：
10.1016/S0891-5849(01)00628-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Brains of hibernating mammals are protected against a variety of insults that are detrimental to humans and other nonhibernating species. Such protection is associated with a number of physiological adaptations including hypothermia, increased antioxidant defense, metabolic arrest, leukocytopenia, immunosuppression, and hypocoagulation. It is intriguing that similar manipulations provide considerable protection as experimental treatments for central nervous system injury. This review focuses on neuroprotective mechanisms employed during hibernation that may offer novel approaches in the treatment of stroke, traumatic brain injury, and neurodegenerative diseases in humans. (C) 2001 Elsevier Science Inc.
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收藏
页码：563 / 573
页数：11
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