Results from the 2nd Scientific Workshop of the ECCO (I): Impact of mucosal healing on the course of inflammatory bowel disease

被引:271
作者
Peyrin-Biroulet, Laurent [2 ,3 ]
Ferrante, Marc [4 ]
Magro, Fernando [5 ,6 ]
Campbell, Simon [7 ]
Franchimont, Denis [8 ]
Fidder, Herma [9 ]
Strid, Hans [10 ]
Ardizzone, Sandro [11 ]
Veereman-Wauters, Gigi [12 ]
Chevaux, Jean-Baptiste [2 ,3 ]
Allez, Mathieu [13 ]
Danese, Silvio [14 ]
Sturm, Andreas [1 ]
机构
[1] Univ Med Berlin, Charite, Campus Virchow Clin, Div Gastroenterol & Hepatol, D-13353 Berlin, Germany
[2] Univ Henri Poincare 1, Univ Hosp Nancy, INSERM, U954, Vandoeuvre Les Nancy, France
[3] Univ Henri Poincare 1, Univ Hosp Nancy, Dept Hepatogastroenterol, Vandoeuvre Les Nancy, France
[4] Univ Hosp Gasthuisberg, Dept Gastroenterol, B-3000 Louvain, Belgium
[5] Univ Porto, Fac Med, Inst Pharmacol & Therapeut, Oporto, Portugal
[6] Hosp Sao Joao, Dept Gastroenterol, Oporto, Portugal
[7] Cent Manchester Univ Hosp NHS Trust, Dept Gastroenterol, Manchester, Lancs, England
[8] Univ Libre Bruxelles, Lab Gastroenterol Expt, B-1070 Brussels, Belgium
[9] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands
[10] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Internal Med, Gothenburg, Sweden
[11] Univ Milan, L Sacco Univ Hosp, Dept Gastroenterol Surg Oncol, Milan, Italy
[12] UZ Brussels, Brussels, Belgium
[13] Univ Paris Diderot, Hop St Louis, APHP, Dept Gastroenterol, Paris, France
[14] Ist Clin Humanitas, Dept Gastroenterol, Milan, Italy
关键词
Inflammatory Bowel Disease; Ulcerative colitis; Crohn's disease; Mucosal healing; DIAGNOSED CROHNS-DISEASE; ULCERATIVE-COLITIS; RISK-FACTOR; COLORECTAL NEOPLASIA; MAINTENANCE THERAPY; PREDICTIVE FACTORS; TERM; INFLIXIMAB; REMISSION; CORTICOSTEROIDS;
D O I
10.1016/j.crohns.2011.06.009
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Over the past years, mucosal healing has emerged as a major therapeutic goal in clinical trials in inflammatory bowel diseases. Accumulating evidence indicates that mucosal healing may change the natural course of the disease by decreasing the need for surgery and reducing hospitalization rates in both ulcerative colitis and Crohn's disease. Mucosal healing may also prevent the development of long-term disease complications, such as bowel damage in Crohn's disease and colorectal cancer in ulcerative colitis. Histologic healing may be the ultimate therapeutic goal in ulcerative colitis, whereas its impact on the course of Crohn's disease is unknown. Complete mucosal healing may be required before considering drug withdrawal. Targeting early Crohn's disease is more effective than approaches aimed at healing mucosa in longstanding disease. Several questions remain to be answered: should mucosal healing be systematically used in clinical practice? Should we optimize therapies to achieve mucosal healing? What is the degree of intestinal healing that is required to change the disease course? Large prospective studies addressing these issues are needed. (C) 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:477 / 483
页数:7
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