Effect of Subcutaneous Unfractionated Heparin Prophylaxis on Activated Partial Thromboplastin Time: A Retrospective Evaluation

被引：9

作者：

Thompson, Molly H. ^{[1
]}

Wilson, Sylvia H. ^{[2
]}

Toussaint, Brittany L. ^{[1
]}

Jordan, Cameron L. ^{[1
]}

Hayes, Genevieve L. ^{[1
]}

McKinzie, Brian P. ^{[1
]}

Wolf, Bethany J. ^{[3
]}

Field, Larry C. ^{[2
]}

机构：

[1] Med Univ South Carolina, Dept Pharm Serv, 150 Ashley Ave,MSC 584, Charleston, SC 29425 USA

[2] Med Univ South Carolina, Dept Anesthesia & Perioperat Med, 167 Ashley Ave,Suite 301,MSC 912, Charleston, SC 29425 USA

[3] Med Univ South Carolina, Dept Publ Hlth Sci, 135 Cannon St,Suite 303,MSC 835, Charleston, SC 29425 USA

来源：

JOURNAL OF CLINICAL ANESTHESIA | 2016年 / 33卷

关键词：

Unfractionated heparin; Venous thromboembolism prophylaxis; Activated partial thromboplastin time; DEEP-VEIN THROMBOSIS; NEURAXIAL ANESTHESIA; PULMONARY-EMBOLISM; VENOUS THROMBOSIS; ANALGESIA; OBESITY; TRIALS;

D O I：

10.1016/j.jclinane.2015.11.020

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Study Objective: Characterize the incidence of elevated aPTT results in patients treated with prophylactic, subcutaneous unfractionated heparin (UFH). Design: Retrospective, cohort analysis. Setting: Single-center, university hospital. Measurements: Evaluation of 257 patients with activated partial thromboplastin time (aPTT) testing both prior to and following subcutaneous (SC) unfractionated heparin (UFH) therapy. Main Results: Evaluated patients received UFH 5000 units every 8 hours. Baseline aPTT values were within the normal range (mean +/- SD, 32.0 +/- 8.5 seconds). After initiation of UFH, aPTT values increased (mean SD, 37.6 +/- 15.2 seconds). After 24 hours of SC UFH, mean aPTT values (mean SD, 38.6 +/- 15.5) exceeded the normal laboratory range (23.3-35.7 seconds). An elevated aPTT result after UFH was associated with baseline aPTT, length of therapy, and weight-based UFH dose. A significant association was not identified between aPTT elevation and age, race, sex, history of liver disease, type of admission, or transfusion of blood products. Conclusions: Treatment with UFH resulted in a small, but significant, increase in aPTT. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：346 / 350

页数：5