Higher-order motif analysis in hypergraphs

Recent research has shown that pair interactions in a given network are superseded by higher-order interactions and to incorporate these features into our understanding of a network additional mathematical tools, such as hypergraphs, are required. Here, the authors develop an algorithm to detect motifs in hypergraphs and show how they can be used to identify structural differences in a variety of real-world systems. A deluge of new data on real-world networks suggests that interactions among system units are not limited to pairs, but often involve a higher number of nodes. To properly encode higher-order interactions, richer mathematical frameworks such as hypergraphs are needed, where hyperedges describe interactions among an arbitrary number of nodes. Here we systematically investigate higher-order motifs, defined as small connected subgraphs in which vertices may be linked by interactions of any order, and propose an efficient algorithm to extract complete higher-order motif profiles from empirical data. We identify different families of hypergraphs, characterized by distinct higher-order connectivity patterns at the local scale. We also propose a set of measures to study the nested structure of hyperedges and provide evidences of structural reinforcement, a mechanism that associates higher strengths of higher-order interactions for the nodes that interact more at the pairwise level. Our work highlights the informative power of higher-order motifs, providing a principled way to extract higher-order fingerprints in hypergraphs at the network microscale.