Radiation, inflammation and the immune response in cancer

被引：150

作者：

McKelvey, Kelly J. ^{[1
,2
,3
]}

Hudson, Amanda L. ^{[1
,2
,3
]}

Back, Michael ^{[2
,4
]}

Eade, Tom ^{[4
]}

Diakos, Connie I. ^{[3
,4
]}

机构：

[1] Univ Sydney, Bill Walsh Translat Canc Res Lab, Northern Sydney Local Hlth Dist Res & Northern Cl, St Leonards, NSW 2065, Australia

[2] North Shore Private Hosp, Sydney Neurooncol Grp, St Leonards, NSW 2065, Australia

[3] Royal North Shore Hosp, Sydney Vital Translat Res Ctr, St Leonards, NSW 2065, Australia

[4] Royal North Shore Hosp, Northern Sydney Canc Ctr, St Leonards, NSW 2065, Australia

来源：

MAMMALIAN GENOME | 2018年 / 29卷 / 11-12期

关键词：

TOTAL-BODY IRRADIATION; DOUBLE-STRAND BREAKS; REGULATORY T-CELLS; INDUCED BYSTANDER RESPONSES; FIELD GEL-ELECTROPHORESIS; IONIZING-RADIATION; DNA-DAMAGE; ENDOTHELIAL-CELLS; UP-REGULATION; MOLECULAR-MECHANISMS;

D O I：

10.1007/s00335-018-9777-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Radiation is an important component of cancer treatment with more than half of all patients receive radiotherapy during their cancer experience. While the impact of radiation on tumour morphology is routinely examined in the pre-clinical and clinical setting, the impact of radiation on the tumour microenvironment and more specifically the inflammatory/immune response is less well characterised. Inflammation is a key contributor to short- and long-term cancer eradication, with significant tumour and normal tissue consequences. Therefore, the role of radiation in modulating the inflammatory response is highly topical given the current wave of targeted and immuno-therapeutic treatments for cancer. This review provides a general overview of how radiation modulates the inflammatory and immune response(i) how radiation induces the inflammatory/immune system, (ii) the cellular changes that take place, (iii) how radiation dose delivery affects the immune response, and (iv) a discussion on research directions to improve patient survival, reduce side effects, improve quality of life, and reduce financial costs in the immediate future. Harnessing the benefits of radiation on the immune response will enhance its maximal therapeutic benefit and reduce radiation-induced toxicity.

引用

页码：843 / 865

页数：23

共 215 条

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