Biocompatible fluorenylphthalocyanines for one- and two-photon photodynamic therapy and fluorescence imaging

被引：15

作者：

Abid, Seifallah ^{[1
,4
]}

Nguyen, Christophe ^{[2
]}

Daurat, Morgane ^{[3
]}

Durand, Denis ^{[2
]}

Jamoussi, Bassem ^{[4
,5
]}

Blanchard-Desce, Mireille ^{[6
]}

Gary-Bobo, Magali ^{[2
]}

Mongin, Olivier ^{[1
]}

Paul-Roth, Christine O. ^{[1
]}

Paul, Frederic ^{[1
]}

机构：

[1] Univ Rennes, ISCR Inst Sci Chim Rennes, CNRS, INSA Rennes,UMR 6226, F-35000 Rennes, France

[2] Univ Montpellier, ENSCM, CNRS, IBMM, Montpellier, France

[3] NanoMedSyn, 15 Ave Charles Flahault, F-34093 Montpellier 05, France

[4] Univ Carthage, Fac Sci Bizerte, Tunis, Tunisia

[5] King Abdulaziz Univ, Fac Meteorol Environm & Arid Land Agr, Dept Environm Sci, Jeddah, Saudi Arabia

[6] Univ Bordeaux, Inst Sci Mol, CNRS, UMR 5255, F-33405 Talence, France

来源：

DYES AND PIGMENTS | 2022年 / 197卷

关键词：

Phthalocyanine; Fluorene; Two-photon absorption; Oxygen sensitization; Photodynamic therapy; Fluorescence imaging; NONLINEAR-OPTICAL PROPERTIES; SINGLET OXYGEN GENERATION; CORED DERIVATIVES; QUANTUM YIELDS; PHOTOSENSITIZERS; PHTHALOCYANINES; CHROMOPHORES; ABSORPTION; PORPHYRIN; NANOPARTICLES;

D O I：

10.1016/j.dyepig.2021.109840

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The synthesis and the optical properties of a family of new fluorenyl phthalocyanines substituted with watersolubilizing triethyleneglycol chains is described. These biocompatible molecules exhibit strong one- and twophoton absorptions, together with fluorescence and photosensitization properties similar to those of their lipophilic analogues, thus outperforming unsubstituted zinc phthalocyanine in terms of brightness and singlet oxygen production. They were subsequently probed in vitro on cancer cells under one and two-photon excitation in both fluorescence imaging and photodynamic therapy experiments. The metal-free compound was shown to be more biocompatible and thus more promising than the zinc complex for theranostic applications.

引用

页数：8

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