Functions and Mechanisms of Long Noncoding RNAs in Ovarian Cancer

被引：78

作者：

Ren, Chengcheng ^{[1
]}

Li, Xiaobo ^{[1
]}

Wang, Tianzhen ^{[1
]}

Wang, Guangyu ^{[3
]}

Zhao, Ci ^{[3
]}

Liang, Tian ^{[1
]}

Zhu, Yuanyuan ^{[1
]}

Li, Minghui ^{[4
]}

Yang, Chao ^{[1
]}

Zhao, Yunlong ^{[1
]}

Zhang, Guang-mei ^{[2
]}

机构：

[1] Harbin Med Univ, Harbin 150001, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China

[3] Harbin Med Univ, Affiliated Tumor Hosp, Harbin 150001, Heilongjiang, Peoples R China

[4] Inner Mongolia Med Coll, Hohhot, Peoples R China

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | 2015年 / 25卷 / 04期

关键词：

LncRNA; Ovarian cancer; Gene expression; Gene regulation; EXPRESSION; H19; CHROMATIN;

D O I：

10.1097/IGC.0000000000000413

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long noncoding RNAs (lncRNAs) are longer than 200-nucleotide, noncoding transcripts in length, have a variety of biological functions, and are closely associated with tumor development. Ovarian cancer, as 1 of the 3 common gynecological malignancies, is the leading cause of death in women with gynecological malignant tumor. In this study, a review of the literature found that lncRNAs H19, LSINCT5, and XIST have a close relationship to the development of ovarian cancer occurrence, growth, invasion, and metastasis, and they can promote ovarian cancer cell proliferation. Hence, in this article, the progress of above-mentioned 3 kinds of lncRNAs in ovarian cancer was reviewed and designed to help in the diagnosis, treatment, and prognosis of ovarian cancer.

引用

页码：566 / 569

页数：4

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