DNA methyltransferases and structural-functional specificity of eukaryotic DNA modification

被引：42
作者：
Buryanov, YI [1 ]
Shevchuk, TV [1 ]
机构：
[1] Russian Acad Sci, Pushchino Branch, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Pushchino 142290, Moscow Region, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2005年 / 70卷 / 07期
基金：
俄罗斯基础研究基金会;
关键词：
DNA; methylation; DNA methyltransferases; CpG; CpNpG; and CpNpN sequences; structure; functions; eukaryotes;
D O I：
10.1007/s10541-005-0178-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Properties of the main families of mammalian, plant, and fungal DNA methyltransferases are considered. Structural-functional specificity of eukaryotic genome sequences methylated by DNA methyltransferases is characterized. The total methylation of cytosine in DNA sequences is described, as well as its relation with RNA interference. Mechanisms of regulation of expression and modulation of DNA methyltransferase activity in the eukaryotic cell are discussed.
引用
收藏
页码：730 / 742
页数：13
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