Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation

被引：42

作者：

Ohta, Yusuke ^{[1
]}

Oishi, Shinya ^{[1
]}

Fujii, Nobutaka ^{[1
]}

Ohno, Hiroaki ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 07期

关键词：

D O I：

10.1039/b718201e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copper(I)-catalysed domino four-component coupling-cyclisation using 2-ethynylbenzaldehydes, paraformaldehyde, secondary amine, and t-BuNH2 in DMF leads to direct and efficient formation of 3-(aminomethyl)isoquinolines in good to high yields.

引用

页码：835 / 837

页数：3

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