Kinetics of the Solution-Mediated Polymorphic Transformation of Organic Compounds

被引：7

作者：

Wantha, Lek ^{[1
]}

机构：

[1] Burapha Univ, Fac Engn, Dept Chem Engn, 169 Long Hard Bangsaen Rd, Chon Buri 20131, Thailand

来源：

CURRENT PHARMACEUTICAL DESIGN | 2018年 / 24卷 / 21期

关键词：

Polymorphism; organic compound; crystallization from solution; kinetics; solution-mediated polymorphic transformation; process modelling; L-GLUTAMIC ACID; ACTIVE PHARMACEUTICAL INGREDIENTS; POPULATION BALANCE MODEL; DRUG-DELIVERY SYSTEM; FORM III PIRACETAM; SOLID-STATE; NUCLEATION KINETICS; CRYSTALLIZATION BEHAVIOR; DISSOLUTION KINETICS; PHASE-TRANSFORMATION;

D O I：

10.2174/1381612824666180601093228

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polymorphism is a behavior of a substance to crystallize into more than one district crystal structures. Preferential formation of a polymorph depends strongly on the kinetics of the relevant mechanisms. Solution-mediated polymorphic transformation is an important mechanism in crystallization of organic compounds from solution. Knowing its kinetics allows us to understand the process and control the polymorphic formation. In this review, concepts, kinetics, and process modeling of crystallization and solution-mediated polymorphic transformation are examined and summarized.

引用

页码：2383 / 2393

页数：11

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