Restoring stem cells - all you need is NAD+

被引：15

作者：

Wu, Lindsay E. ^{[1
]}

Sinclair, David A. ^{[1
,2
]}

机构：

[1] UNSW Australia, Sch Med Sci, Sydney, NSW 2052, Australia

[2] Harvard Med Sch, Dept Genet, Glenn Labs Biol Mech Aging, Boston, MA 02115 USA

来源：

CELL RESEARCH | 2016年 / 26卷 / 09期

关键词：

MITOCHONDRIAL; LONGEVITY;

D O I：

10.1038/cr.2016.80

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The loss of stem cells, through cell dysfunction or senescence, is thought to contribute to biological aging. Recently, Hongbo Zhang and colleagues have shown that activation of the mitochondrial unfolded protein response, a retrograde stress response, through administration with an NAD(+)-raising compound, can rejuvenate stem cells and extend lifespan in mice.

引用

页码：971 / 972

页数：2

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