The Pathophysiology of Anorexia Nervosa in Hypothalamic Endocrine Function and Bone Metabolism

被引:4
作者
Jada, Keji [1 ]
Djossi, Sandrine Kakieu [1 ]
Khedr, Anwar [2 ]
Neupane, Bandana [1 ]
Proskuriakova, Ekaterina [2 ]
Mostafa, Jihan A. [3 ]
机构
[1] Calif Inst Behav Neurosci & Psychol, Res, Fairfield, CA 94534 USA
[2] Calif Inst Behav Neurosci & Psychol, Internal Med, Fairfield, CA USA
[3] Calif Inst Behav Neurosci & Psychol, Psychiat, Fairfield, CA USA
关键词
leptin and gherlin; hypotalamic gonadal axis; hypotalamic thyroid axis; hypotalamic adrenal axis; hypotalamic endocrine function; amenorrhea; bone metabolism; endocrinopathies; anorexia nervosa; CORTICOTROPIN-RELEASING HORMONE; LOW SERUM TRIIODOTHYRONINE; AGOUTI-RELATED PROTEIN; ADOLESCENT GIRLS; BULIMIA-NERVOSA; EATING-DISORDERS; WOMEN; CORTISOL; PLASMA; DENSITY;
D O I
10.7759/cureus.20548
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Anorexia nervosa (AN) is a persistent psychiatric disorder that is marked by abnormal reduced weight and amenorrhea, which may be primary or secondary. AN affects multiple endocrine axes such as gonadal, thyroid, and adrenal axis, growth hormone, and insulin-like growth factor-1, adipokines such as leptin, gut peptides like ghrelin, peptide YY, and amylin. As a result of these changes bone mineral density is reduced, which increases the risk of bone fracture in patients. In this review, we focus on substantial endocrine alterations in AN with a particular emphasis on the severe bone loss associated with this condition and current bone therapies. The disorder primarily affects girls and women, who are the focus of this review. Although the majority of AN-related endocrinopathies improve over time, long-term consequences such as short stature, osteoporosis, and infertility may occur. To avoid serious consequences, nutrition therapy in these patients requires a full understanding of bone complications, and new therapeutic options for treatment should be researched.
引用
收藏
页数:8
相关论文
共 54 条
[1]   Effects of short-term insulin-like growth factor-I (IGF-I) or growth hormone (GH) treatment on bone metabolism and on production of 1,25-dihydroxycholecalciferol in GH-deficient adults [J].
Bianda, T ;
Glatz, Y ;
Bouillon, R ;
Froesch, ER ;
Schmid, C .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (01) :81-87
[2]   ANOREXIA-NERVOSA - IMMATURITY OF 24-HOUR LUTEINIZING-HORMONE SECRETORY PATTERN [J].
BOYAR, RM ;
KATZ, J ;
FINKELSTEIN, JW ;
KAPEN, S ;
WEINER, H ;
WEITZMAN, ED ;
HELLMAN, L .
NEW ENGLAND JOURNAL OF MEDICINE, 1974, 291 (17) :861-865
[3]   A meta-analysis of circulating BDNF concentrations in anorexia nervosa [J].
Brandys, Marek K. ;
Kas, Martien J. H. ;
van Elburg, Annemarie A. ;
Campbell, Iain C. ;
Adan, Roger A. H. .
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2011, 12 (06) :444-454
[4]   Distal Radius in Adolescent Girls with Anorexia Nervosa: Trabecular Structure Analysis with High-Resolution Flat-Panel Volume CT [J].
Bredella, Miriam A. ;
Misra, Madhusmita ;
Miller, Karen K. ;
Madisch, Ijad ;
Sarwar, Ammar ;
Cheung, Arnold ;
Klibanski, Anne ;
Gupta, Rajiv .
RADIOLOGY, 2008, 249 (03) :938-946
[5]   Open issues in anorexia nervosa - Prevention and therapy of bone loss [J].
Bruni, Vincenzina ;
Filicetti, Maria Francesca ;
Pontello, Valentina .
WOMEN'S HEALTH AND DISEASE: GYNECOLOGIC, ENDOCRINE, AND REPRODUCTIVE ISSUES, 2006, 1092 :91-102
[6]   ALTERATIONS IN SERUM CORTISOL AND ITS BINDING CHARACTERISTICS IN ANOREXIA-NERVOSA [J].
CASPER, RC ;
CHATTERTON, RT ;
DAVIS, JM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1979, 49 (03) :406-411
[7]   RELATION BETWEEN ASPECTS OF NUTRITIONAL DISTRUBANCE AND MENSTRUAL ACTIVITY IN PRIMARY ANOREXIA NERVOSA [J].
CRISP, AH ;
STONEHILL, E .
BMJ-BRITISH MEDICAL JOURNAL, 1971, 3 (5767) :149-+
[8]   LOW SERUM TRIIODOTHYRONINE (T3) AND HYPOTHYROIDISM IN ANOREXIA-NERVOSA [J].
CROXSON, MS ;
IBBERTSON, HK .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1977, 44 (01) :167-174
[9]   Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 [J].
de Roux, N ;
Genin, E ;
Carel, JC ;
Matsuda, F ;
Chaussain, JL ;
Milgrom, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :10972-10976
[10]   RAPID ESCAPE OF CORTISOL FROM SUPPRESSION IN RESPONSE TO IV DEXAMETHASONE IN ANOREXIA-NERVOSA [J].
ESTOUR, B ;
PUGEAT, M ;
LANG, F ;
LEJEUNE, H ;
BROUTIN, F ;
PELLET, J ;
ROUSSET, H ;
TOURNIAIRE, J .
CLINICAL ENDOCRINOLOGY, 1990, 33 (01) :45-52