Comparison of blood loss between tranexamic acid-soaked absorbable Gelfoam and topical retrograde injection via drainage catheter plus clamping in cervical laminoplasty surgery

被引：7

作者：

Chen, Chong ^{[1
]}

Ye, Yong-yu ^{[1
]}

Chen, Yi-fan ^{[1
]}

Yang, Xiao-xi ^{[2
]}

Liang, Jin-qian ^{[3
]}

Liang, Guo-yan ^{[1
]}

Zheng, Xiao-qing ^{[1
]}

Chang, Yun-bing ^{[1
]}

机构：

[1] Guangdong Acad Med Sci, Dept Spine Surg, Guangdong Prov Peoples Hosp, 106,Zhongshan 2nd Rd, Guangzhou 510080, Guangdong, Peoples R China

[2] Peking Univ, Dept Orthoped, Peking Univ Third Hosp, 49 Huayuan North Rd, Beijing 100191, Peoples R China

[3] Chinese Acad Med Sci, Dept Orthoped, Peking Union Med Coll Hosp, Peking Union Med Coll, 1 Shuaifuyuan Wangfujing, Beijing 100730, Peoples R China

来源：

BMC MUSCULOSKELETAL DISORDERS | 2022年 / 23卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Tranexamic acid; Perioperative blood loss; Degenerative cervical myelopathy; Cervical laminoplasty; TRANSFUSION; SEIZURES; ARTHROPLASTY;

D O I：

10.1186/s12891-022-05626-w

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Background To compare the safety and efficacy of tranexamic acid (TXA)-soaked absorbable Gelfoam and the retrograde injection of TXA through a drain with drain-clamping in degenerative cervical laminoplasty patients. Methods Patients were assigned into either TXA retrograde injection (TXA-RI), TXA-soaked absorbable Gelfoam (TXA-Gel), or control groups. The demographics, operative measurements, volume and length of drainage, length of hospital stay, complete blood cell count, coagulopathy, postoperative complications, and blood transfusion were recorded. Results We enrolled 133 patients, with 44, 44, and 45 in the TXA-RI, TXA-Gel, and control groups, respectively. The baseline characteristics did not differ significantly among the three groups. The TXA-RI group exhibited a lower volume and length of postoperative drainage compared to the TXA-Gel and control groups (126.60 +/- 31.27 vs. 156.60 +/- 38.63 and 275.45 +/- 75.27 mL; 49.45 +/- 9.70 vs 58.70 +/- 10.46 and 89.31 +/- 8.50 hours, all P < 0.01). The TXA-RI group also had significantly shorter hospital stays compared to the control group (5.31 +/- 1.18 vs 7.50 +/- 1.25 days, P < 0.05) and higher hemoglobin and hematocrit levels (12.58 +/- 1.67 vs 11.28 +/- 1.76 g/dL; 36.62 +/- 3.66% vs 33.82 +/- 3.57%, both P < 0.05) at hospital discharge. In the TXA-RI and TXA-Gel groups, the D-dimmer (DD) and fibrinogen (FIB) were significantly lower than those in the control group after surgery (P < 0.05). None of the patients required blood transfusion. No complications, including thromboembolic events, were reported. Conclusion Topical retrograde injection of TXA through a drain with drain-clamping at the conclusion of unilateral posterior cervical expansive open-door laminoplasty may effectively reduce postoperative blood loss and the length of hospital stays without increasing postoperative complications.

引用

页数：8

共 40 条

[1]

[Anonymous], 2006, Dandelion

[2] Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty - A prospective, randomised, double-blind study of 86 patients [J].